Evidence map›Paper›PMID 35955935›Full record

ArticleInternational journal of molecular sciences2022

A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System.

Loretta László, Hédi Maczelka, Tamás Takács, Anita Kurilla, Álmos Tilajka, László Buday, Virag Vas, Ágota Apáti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Loretta LászlóInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.ORCID 0000-0003-0367-4900
Hédi MaczelkaInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Tamás TakácsInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Anita KurillaInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Álmos TilajkaInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
László BudayInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Virag VasInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.ORCID 0000-0001-7249-6816
Ágota ApátiInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.ORCID 0000-0003-0380-8139
Eötvös Loránd University · HUInstitute of Molecular Life Sciences · HUSemmelweis University · HU

Funding

Centre of Excellence of the Hungarian Academy of Sciences This research was funded by grants from the National Research, Development, and Innovation Fund of Hungary K124045, K128369, FIEK_16-1-2016-0005, HunProtExc 2018-1.2.1-NKP-2018-00005 and cooperation between ELKH TTK and PTE SzKK in areas of internationall
6 · The paper itself

Abstract

Tyrosine kinase substrate with four SH3 domains (Tks4) scaffold protein plays roles in cell migration and podosome formation and regulates systemic mechanisms such as adult bone homeostasis and adipogenesis. Mutations in the Tks4 gene (

Indexed as

Heart Defects, CongenitalHuman Embryonic Stem CellsAdaptor Proteins, Signal TransducingChildCraniofacial AbnormalitiesDevelopmental DisabilitiesHumansOsteochondrodysplasiasRare DiseasesAdaptor Proteins, Signal Transducingcell commitmentCRISPR-Cas9Frank-Ter Haar syndromeFTHShuman embryonic stem cellsmesenchymal stem cellsTks4

Identifiers

PMID35955935
PMCPMC9369304
OpenAlexW4295725676

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.