ArticleInternational journal of molecular sciences2022
Promiscuous Lipase-Catalyzed Knoevenagel-Phospha-Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Lipase-Catalyzed Cyclization of β-Ketothioamides with β-Nitrostyrene for the Synthesis of Tetrasubstituted Dihydrothiophenes.Molecules (Basel, Switzerland) · 2025Article
- Review
- Article
- Hen egg white lysozyme encapsulated in ZIF-8 for performing promiscuous enzymatic Mannich reaction.iScience · 2023Article
- Combined Nanofibrous Face Mask: Co-Formulation of Lipases and Antibiotic Agent by Electrospinning Technique.Pharmaceutics · 2023Article
- A Novel Biocidal Nanocomposite: Spherical Silica with Silver Ions Anchored at the Surface.International journal of molecular sciences · 2022Article
- Lipase-Catalyzed Phospha-Michael Addition Reactions under Mild Conditions.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An enzymatic route for phosphorous-carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the synthesis of pharmacologically relevant β-phosphonomalononitriles via a lipase-catalyzed one-pot Knoevenagel-phospha-Michael reaction. We carefully analyzed the best conditions for the given reaction: the type of enzyme, temperature, and type of solvent. A series of target compounds was synthesized, with yields ranging from 43% to 93% by enzymatic reaction with
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Registered trials
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