Evidence map›Paper›PMID 35956364›Full record

Trial reportNutrients2022

Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study.

Sofía Montemayor, Catalina M Mascaró, Lucía Ugarriza, Miguel Casares, Isabel Llompart, Itziar Abete, María Ángeles Zulet, J Alfredo Martínez, Josep A Tur, Cristina Bouzas

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06908122 (Validity of Laboratory Biomarkers in Diagnosis of Nonalcoholic Fatty Liver Disease), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06908122 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Validity of Laboratory Biomarkers in Diagnosis of Nonalcoholic Fatty Liver Disease (NAFLD) and It's Consequences

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled100ConditionsNon-alcoholic Fatty Liver DiseaseArmslaboratory biomarkers in the diagnosis of NAFLD disease
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Nutritional and Fasting Strategies for the Management of MASLD/MASH: An Integrative Review.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Research Progress on Chemical Components ofMolecules (Basel, Switzerland) · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sofía MontemayorResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.ORCID 0000-0001-7833-2118
Catalina M MascaróResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.
Lucía UgarrizaResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.
Miguel CasaresRadiodiagnosis Service, Red Asistencial Juaneda, 07011 Palma de Mallorca, Spain.
Isabel LlompartResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.
Itziar AbeteCIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.ORCID 0000-0002-6475-5387
María Ángeles ZuletCIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.ORCID 0000-0002-3926-0892
J Alfredo MartínezDepartment of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain.
Josep A TurResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.ORCID 0000-0002-6940-0761
Cristina BouzasResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.
Health Research Institute of the Balearic Islands · ESInstituto de Salud Carlos III · ESMadrid Institute for Advanced Studies · ES

Funding

Directorate General of R+D of the Balearic Islands Government post-doctoral grantFundació La Marató TV3 201630.10IDISBA FOLIUM, PRIMUS, SYNERGIA, and LIBERIInstituto de Salud Carlos III CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03Spanish Ministry of Education FPU PhD grant
6 · The paper itself

Abstract

Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases, which usually have a pathophysiological relationship with NAFLD. To assess the effect of adherence to a MedDiet on NAFLD in MetS patients after lifestyle intervention, this multicentre (Mallorca and Navarra, Spain) prospective randomized trial, with personalized nutritional intervention based on a customized MedDiet, coupled with physical activity promotion was performed to prevent, and reverse NAFLD among patients with MetS. The current analysis included 138 patients aged 40 to 60 years old, Body Mass Index (BMI) 27-40 kg/m

Indexed as

Diabetes Mellitus, Type 2Diet, MediterraneanMetabolic SyndromeNon-alcoholic Fatty Liver DiseaseAdultHumansMiddle AgedProspective Studiesintrahepatic fat contentsMediterranean dietmetabolic syndromeNAFLDnon-alcoholic fat liver disease

Identifiers

PMID35956364
PMCPMC9370227
OpenAlexW4289731551

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.