Evidence map›Paper›PMID 35958027›Full record

ReviewiScience2022

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research.

Bogdan Mateescu, Jennifer C Jones, Roger P Alexander, Eric Alsop, Ji Yeong An, Mohammad Asghari, Alex Boomgarden, Laura Bouchareychas, Alfonso Cayota, Hsueh-Chia Chang and 86 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Condensates on the Move: Midbody Remnants as Large, Translation-Competent Extracellular Vesicles.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  4. The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Molecular hallmarks of ageing in amyotrophic lateral sclerosis.Cellular and molecular life sciences : CMLS · 2024
    Review
  17. Article
  18. Review
  19. The NanoFlow Repository.Bioinformatics (Oxford, England) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

96 authors.

Bogdan MateescuBrain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Jennifer C JonesLaboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Roger P AlexanderExtracellular RNA Communication Consortium, Phoenix, AZ 85254, USA.
Eric AlsopNeurogenomics Division, TGen, Phoenix, AZ 85004, USA.
Ji Yeong AnDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Mohammad AsghariInstitute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland.
Alex BoomgardenDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Laura BouchareychasDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Alfonso CayotaFunctional Genomics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Hsueh-Chia ChangDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Al CharestDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Daniel T ChiuDepartment of Chemistry and Bioengineering, University of Washington, Seattle, WA 98195, USA.
Robert J CoffeyDepartment of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Peter De HoffDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA.
Andrew deMelloInstitute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland.
Crislyn D'Souza-SchoreyDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
David ElashoffStatistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kiarash R EliatoDepartment of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Jeffrey L FranklinDepartment of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
David J GalasPacific Northwest Research Institute, Seattle, WA 98122, USA.
Mark B GersteinDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Ionita H GhiranDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
David B GoDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Stephen GouldDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Tristan R GroganDepartment of Medicine Statistics Core, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
James N HigginbothamDepartment of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Florian HladikDepartments of Obstetrics and Gynecology, and Medicine, University of Washington, Seattle, WA, USA.
Tony Jun HuangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA.
Xiaoye HuoDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Elizabeth HutchinsNeurogenomics Division, TGen, Phoenix, AZ 85004, USA.
Dennis K JeppesenDepartment of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Tijana Jovanovic-TalismanDepartment of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Betty Y S KimDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sung KimDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Kyoung-Mee KimDepartment of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Yong KimDepartment of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA.
Robert R KitchenCorrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Vaughan KnouseLaboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Emily L LaPlanteBioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA 95616, USA.
L James LeeDepartment of Chemical and Biomolecular Engineering and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Kathleen M LennonDepartment of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Guoping LiCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Feng LiDepartment of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA.
Tieyi LiDepartment of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA.
Tao LiuBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Zirui LiuDepartment of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA.
Adam L MaddoxDepartment of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Kyle McCarthyDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Bessie MeechoovetNeurogenomics Division, TGen, Phoenix, AZ 85004, USA.
Nalin ManiyaDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Yingchao MengInstitute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland.
Aleksandar MilosavljevicBioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Byoung-Hoon MinDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, South Korea.
Amber MoreyDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA.
Martin NgNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
John NolanScintillon Institute, San Diego, CA, USA.
Getulio P De Oliveira JuniorDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Michael E PaulaitisCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tuan Anh PhuNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Robert L RaffaiDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Eduardo ReáteguiDepartment of Chemical and Biomolecular Engineering and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Matthew E RothBioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
David A RoutenbergMeso Scale Diagnostics, LLC, Rockville, MD 20850, USA.
Joel RozowskyDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Joseph RufoDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA.
Satyajyoti SenapatiDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Sigal ShacharMeso Scale Diagnostics, LLC, Rockville, MD 20850, USA.
Himani SharmaDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Anil K SoodDepartment of Gynecologic Oncology & Reproductive Medicine, University of Texas MD Aderson Cancer Center, Houston, TX 77030, USA.
Stavros StavrakisInstitute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland.
Alessandra StürchlerBrain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Muneesh TewariDepartment of Internal Medicine, Hematology/Oncology Division, University of Michigan, Ann Arbor, MI 48109, USA.
Juan P TosarFunctional Genomics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Alexander K Tucker-SchwartzMeso Scale Diagnostics, LLC, Rockville, MD 20850, USA.
Andrey TurchinovichCancer Genome Research (B063), German Cancer Research Center DKFZ, Heidelberg 69120, Germany.
Nedyalka ValkovCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Kendall Van Keuren-JensenNeurogenomics Division, TGen, Phoenix, AZ 85004, USA.
Kasey C VickersDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Lucia VojtechDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA.
Wyatt N VreelandBioprocess Measurement Group, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Ceming WangDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Kai WangInstitute for Systems Biology, Seattle, WA 98109, USA.
ZeYu WangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA.
Joshua A WelshLaboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
David T W WongDepartment of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA.
Jianping XiaDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA.
Ya-Hong XieDepartment of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA.
Kaichun YangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA.
Mikołaj P ZaborowskiDepartment of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland.
Chenguang ZhangDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Qin ZhangDepartment of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Angela M ZivkovicDepartment of Nutrition, University of California, Davis, CA 95616, USA.
Louise C LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KON, VALENTINA · 2014 to 2025
$24.7M
Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEPHEN W. FESIK · 2019 to 2026
$19.6M
Roles for Supermeres in CRC ProgressionP01CA229123 · NCI · VANDERBILT UNIVERSITY · PI Alissa M Weaver · 2020 to 2026
$12.9M
Integrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4M
Development and use of nanoFACS for analysis and sorting of nanoparticlesZIABC011502 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$8.6M
Novel Combinations of Radiation and ImmunotherapyZIABC011503 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$5.3M
Scientific Outreach ComponentU54DA049098 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI ROTH, MATT · 2019 to 2022
$5.0M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
Next-generation extracellular vesicle biologics to target central nervous system and peripheral reservoirs of HIVR01AI144997 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RAMRATNAM, BHARAT, WITWER, KENNETH W · 2019 to 2023
$4.0M
Extracellular Vesicle and Extracellular RNA Biomarkers of HIV-1 Central Nervous System Pathogenesis and Cigarette UseR01DA047807 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2018 to 2022
$3.7M
Comprehensive Characterization of Glycosylation Alterations in Alzheimer’s DiseaseR01AG062240 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JIN, LEE-WAY, LEBRILLA, CARLITO B · 2018 to 2022
$3.3M
NCATS NIH HHS UG3 TR002874NCATS NIH HHS UG3 TR002878NCATS NIH HHS UG3 TR002881NCATS NIH HHS UG3 TR002884NCATS NIH HHS UG3 TR002886NCATS NIH HHS UG3 TR002978NCATS NIH HHS UH3 TR002881NCATS NIH HHS UH3 TR002886NCI NIH HHS P01 CA229123NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA236733NCI NIH HHS R01 CA260958NCI NIH HHS R35 CA197570NCI NIH HHS UG3 CA241684NCI NIH HHS UG3 CA241685NCI NIH HHS UG3 CA241687NCI NIH HHS UG3 CA241694NCI NIH HHS UG3 CA241703NCI NIH HHS UH3 CA241694NHLBI NIH HHS P01 HL116263NIAID NIH HHS R01 AI144997NIA NIH HHS R01 AG062240NICHD NIH HHS T32 HD007203NIDA NIH HHS R01 DA040386NIDA NIH HHS R01 DA047807NIDA NIH HHS U54 DA049098NIGMS NIH HHS R01 GM147545NIMH NIH HHS R21 MH118164NIMH NIH HHS R33 MH118164
6 · The paper itself

Abstract

The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013-2018), Phase 2 of the program (ERCC2, 2019-2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.

Indexed as

BiochemistryBiological sciencesCell biologyMolecular biology

Identifiers

PMID35958027
PMCPMC9358052

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.