Evidence map›Paper›PMID 35960654›Full record

ArticleAnalytical chemistry2022

Boost-DiLeu: Enhanced Isobaric

Danqing Wang, Min Ma, Junfeng Huang, Ting-Jia Gu, Yusi Cui, Miyang Li, Zicong Wang, Henrik Zetterberg, Lingjun Li

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Article
  9. Functional Analysis of Mannosyltransferase-Related GenesInternational journal of molecular sciences · 2025
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Danqing WangDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0001-8080-9675
Min MaSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Junfeng HuangSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0002-1672-3751
Ting-Jia GuSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Yusi CuiDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Miyang LiDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Zicong WangSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Henrik ZetterbergInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg 43141, Sweden.
Lingjun LiDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-0056-3869
University of Wisconsin–Madison · USSahlgrenska University Hospital · SE

Funding

TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's diseaseRF1AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$2.4M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
MULTIPLEX CHEMICAL TAGS FOR HIGH-THROUGHPUT GLYCAN AND GLYCOPEPTIDE QUANTITATION AND CHARACTERIZATIONU01CA231081 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2020
$1.3M
Acquisition of a High Resolution High Speed MALDI Mass Spectrometer for Biomedical Research at UW-MadisonS10OD025084 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$598k
Probing Protein Structural Changes in Alzheimers DiseaseR21AG065728 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2020 to 2020
$420k
NCI NIH HHS U01 CA231081NCRR NIH HHS S10 RR029531NIA NIH HHS R21 AG065728NIA NIH HHS RF1 AG052324NIDDK NIH HHS R01 DK071801NIGMS NIH HHS P41 GM108538NIH HHS S10 OD025084
6 · The paper itself

Abstract

Intact glycopeptide analysis has been of great interest because it can elucidate glycosylation site information and glycan structural composition at the same time. However, mass spectrometry (MS)-based glycoproteomic analysis is hindered by the low abundance and poor ionization efficiency of glycopeptides. Relatively large amounts of starting materials are needed for the enrichment, which makes the identification and quantification of intact glycopeptides from samples with limited quantity more challenging. To overcome these limitations, we developed an improved isobaric labeling strategy with an additional boosting channel to enhance

Indexed as

GlycopeptidesHeLa CellsHumansLeucineMass SpectrometryGlycopeptidesLeucineN,N-dimethyl leucine

Identifiers

PMID35960654
PMCPMC9966376
OpenAlexW4290861716

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.