SynthesisPloS one2022
Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Treatments for partial remission of major depressive disorder: a systematic review and meta-analysis.BMJ mental health · 2023Pooled it
- Conversational AI should fill the white space in mental health care, not replace humans.NPJ digital medicine · 2026Review
- How can patients with anxiety and/or depression maintain wellbeing following discharge from low-intensity interventions? A qualitative exploration of patient perspectives.BMC psychiatry · 2026Article
- Therapy after therapy: Entry rates into subsequent psychological treatment among patients receiving therapist-guided internet-delivered or face-to-face psychotherapy.The British journal of clinical psychology · 2026Article
- Digital Physical Activity Interventions for Mental Health Promotion of and Reduction in Addictive Behaviors: Integrative Comprehensive Review with a Focus on Personalization and Implementation.International journal of environmental research and public health · 2026Review
- Effectiveness of mindful breathing exercises on symptom reduction and quality of life in individuals with major depressive disorder: A systematic review.The South African journal of physiotherapy · 2026Review
- Examining varying number of intervention-modules and change in individual networks in young people remitted from depression or anxiety: Exploratory outcomes of the StayFine randomized clinical trial.Neuroscience applied · 2026Article
- Requirements and Concerns of Individuals Remitted From Depression for an Early Relapse Detection mHealth App: Focus Group Study.JMIR mHealth and uHealth · 2025Article
- Predictors and Correlates of Depression and Anxiety Symptom Trajectories in a Large Digital Mental Health Provider: Retrospective Analysis of Data From Rula Health.Journal of medical Internet research · 2025Article
- Evaluating the necessity of booster sessions in relapse prevention for depression: a longitudinal study.Frontiers in psychology · 2025Article
- Anxiety and Depression in Family Members of Critically III Covid-19 Inpatients: Brief Psychological Interventions via Telephone, an Exploratory Study [Letter].Journal of multidisciplinary healthcare · 2023Article
- The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines.Frontiers in psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this review is to establish the effectiveness of psychological relapse prevention interventions, as stand-alone interventions and in combination with maintenance antidepressant treatment (M-ADM) or antidepressant medication (ADM) discontinuation for patients with remitted anxiety disorders or major depressive disorders (MDD).
methodsA systematic review and a meta-analysis were conducted. A literature search was conducted in PubMed, PsycINFO and Embase for randomised controlled trials (RCTs) comparing psychological relapse prevention interventions to treatment as usual (TAU), with the proportion of relapse/recurrence and/or time to relapse/recurrence as outcome measure.
resultsThirty-six RCTs were included. During a 24-month period, psychological interventions significantly reduced risk of relapse/recurrence for patients with remitted MDD (RR 0.76, 95% CI: 0.68-0.86, p<0.001). This effect persisted with longer follow-up periods, although these results were less robust. Also, psychological interventions combined with M-ADM significantly reduced relapse during a 24-month period (RR 0.76, 95% CI: 0.62-0.94, p = 0.010), but this effect was not significant for longer follow-up periods. No meta-analysis could be performed on relapse prevention in anxiety disorders, as only two studies focused on relapse prevention in anxiety disorders.
conclusionsIn patients with remitted MDD, psychological relapse prevention interventions substantially reduce risk of relapse/recurrence. It is recommended to offer these interventions to remitted MDD patients. Studies on anxiety disorders are needed. SYSTEMATIC REVIEW REGISTRATION NUMBER: PROSPERO 2018: CRD42018103142.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.