Evidence map›Paper›PMID 35961385›Full record

ReviewNeuroscience and biobehavioral reviews2022

Epigenetic mechanisms regulate cue memory underlying discriminative behavior.

Andrea Shang, Kasia M Bieszczad

Open access · hybridAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. The alkenes Z9-CNature communications · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrea ShangDept. of Psychology - Behavioral and Systems Neuroscience, Rutgers University - New Brunswick, 152 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Kasia M BieszczadDept. of Psychology - Behavioral and Systems Neuroscience, Rutgers University - New Brunswick, 152 Frelinghuysen Road, Piscataway, NJ 08854, USA; Rutgers Center for Cognitive Science (RuCCS), Rutgers University, Piscataway, NJ 08854, USA; Department of Otolaryngology - Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08854, USA. Electronic address: kasia.bie@rutgers.edu.
Johnson University · USRutgers, The State University of New Jersey · US

Funding

Molecular epigenetic mechanisms that transform the auditory system for learning and memoryR01DC018561 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI BIESZCZAD, KASIA · 2020 to 2024
$2.2M
NIDCD NIH HHS R01 DC018561
6 · The paper itself

Abstract

The burgeoning field of neuroepigenetics has introduced chromatin modification as an important interface between experience and brain function. For example, epigenetic mechanisms like histone acetylation and DNA methylation operate throughout a lifetime to powerfully regulate gene expression in the brain that is required for experiences to be transformed into long-term memories. This review highlights emerging evidence from sensory models of memory that converge on the premise that epigenetic regulation of activity-dependent transcription in the sensory brain facilitates highly precise memory recall. Chromatin modifications may be key for neurophysiological responses to transient sensory cue features experienced in the "here and now" to be recapitulated over the long term. We conclude that the function of epigenetic control of sensory system neuroplasticity is to regulate the amount and type of sensory information retained in long-term memories by regulating neural representations of behaviorally relevant cues that guide behavior. This is of broad importance in the neuroscience field because there are few circumstances in which behavioral acts are devoid of an initiating sensory experience.

Indexed as

CuesEpigenesis, GeneticChromatinDNA MethylationHistonesHumansMemoryChromatinHistonesBehaviorCue memoryDNA methylationEpigeneticsHistone acetylationLearningMemoryNeurophysiologyNeuroplasticityNeuroscienceSensory systems

Identifiers

PMID35961385
PMCPMC10353403
OpenAlexW4290792311

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.