ArticleCommunications biology2022
Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans: A Systematic Review and Meta-Analysis.JAMA psychiatry · 2025Pooled it
- Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises.Molecular psychiatry · 2025Trial
- Computational modelling and neural correlates of reinforcement learning following three-week escitalopram: a double-blind, placebo-controlled semi-randomised study.Translational psychiatry · 2025Trial
- Differences in interactions between brain regions across personality types while learning in zebrafish (bioRxiv : the preprint server for biology · 2026Article
- Belief updating in uncertain environments is differentially sensitive to reward and punishment learning: Evidence from ERP.iScience · 2026Article
- Antidepressant drugs have pharmacological- and time-dependent effects on reinforcement learning in healthy volunteers: An 8 weeks randomized double-blind placebo-controlled study.medRxiv : the preprint server for health sciences · 2026Article
- Implementation of active methodologies: a six-phase instructional design model from a neuroeducational perspective.Frontiers in human neuroscience · 2026Article
- Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Article
- Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex.Brain sciences · 2024Review
- Direct serotonin release in humans shapes aversive learning and inhibition.Nature communications · 2024Article
- 5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence.Psychopharmacology · 2024Article
- Article
- The involvement of serotonin in major depression: nescience in disguise?Molecular psychiatry · 2024Article
- Leveraging Decision Science to Characterize Depression.Current directions in psychological science · 2023Article
- Boosting Serotonin Increases Information Gathering by Reducing Subjective Cognitive Costs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Flexibility in valenced reinforcement learning computations across development.Child development · 2022Article
- Dopamine and serotonin interplay for valence-based spatial learning.Cell reports · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Instrumental learning is driven by a history of outcome success and failure. Here, we examined the impact of serotonin on learning from positive and negative outcomes. Healthy human volunteers were assessed twice, once after acute (single-dose), and once after prolonged (week-long) daily administration of the SSRI citalopram or placebo. Using computational modelling, we show that prolonged boosting of serotonin enhances learning from punishment and reduces learning from reward. This valence-dependent learning asymmetry increases subjects' tendency to avoid actions as a function of cumulative failure without leading to detrimental, or advantageous, outcomes. By contrast, no significant modulation of learning was observed following acute SSRI administration. However, differences between the effects of acute and prolonged administration were not significant. Overall, these findings may help explain how serotonergic agents impact on mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.