Evidence map›Paper›PMID 35962800›Full record

ArticleArchives of toxicology2022

CuO-NPs-triggered heterophil extracellular traps exacerbate liver injury in chicks by promoting oxidative stress and inflammatory responses.

Liqiang Jiang, Wei Liu, Jingnan Xu, Xinxin Gao, Haiguang Zhao, Shurou Li, Wenlong Huang, Zhengtao Yang, Zhengkai Wei

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Acta biochimica et biophysica Sinica · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Liqiang Jiang *College of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Wei Liu *College of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Jingnan XuCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Xinxin GaoCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Haiguang ZhaoCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Shurou LiCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Wenlong HuangCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Zhengtao YangCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China.
Zhengkai WeiCollege of Life Sciences and Engineering, Foshan University, Foshan, 528225, Guangdong Province, People's Republic of China. wei_zhengkai@126.com.ORCID 0000-0002-3413-3018
Foshan University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2019A1515110524National Natural Science Foundation of China 32002309
6 · The paper itself

Abstract

With the widespread use of copper oxide nanoparticles (CuO-NPs), their potential toxicity to the environment and biological health has attracted close attention. Heterophil extracellular traps (HETs) are an innate immune mechanism of chicken heterophils against adverse stimuli, but excessive HETs cause damage. Here, we explored the effect and mechanism of CuO-NPs on HETs formation in vitro and further evaluated the potential role of HETs in chicken liver and kidney injury. Heterophils were exposed to 5, 10, and 20 µg/mL of CuO-NPs for 2 h. The results showed that CuO-NPs induced typical HETs formation, which was dependent on NADPH oxidase, P38 and extracellular regulated protein kinases (ERK

Indexed as

Extracellular TrapsMetal NanoparticlesAnimalsCaspasesChickensCopperCyclooxygenase 2Deoxyribonuclease IInterleukin-6LiverNADPH OxidasesNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressOxidesProtein KinasesRNA, MessengerCaspasesCoppercupric oxideCyclooxygenase 2Deoxyribonuclease IInterleukin-6NADPH OxidasesNLR Family, Pyrin Domain-Containing 3 ProteinOxidesProtein KinasesRNA, MessengerSuperoxide DismutaseTumor Necrosis Factor-alphaChickenCuO-NPsHeterophile extracellular trapsLiver damageOxidative stress

Identifiers

PMID35962800
OpenAlexW4291115302

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.