Evidence map›Paper›PMID 35963787›Full record

ReviewHuman immunology2022

Immunogenicity, effectiveness, safety and psychological impact of COVID-19 mRNA vaccines.

Alessio Alesci, Marco Gitto, Magdalena Kotańska, Patrizia Lo Cascio, Anthea Miller, Noemi Nicosia, Angelo Fumia, Simona Pergolizzi

Open access · greenAbstract readReview
In one paragraph

Review in Human immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Current research trends of nanomedicines.Acta pharmaceutica Sinica. B · 2023
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alessio AlesciDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy. Electronic address: alessio.alesci@gmail.com.
Marco GittoDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy; Phoniatric Unit, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, 20157 Milan, Italy. Electronic address: marcogitto.91@gmail.com.
Magdalena KotańskaDepartment of Pharmacological Screening, Jagiellonian University, Medical College, PL 30-688 Cracow, Poland. Electronic address: magda.dudek@uj.edu.pl.
Patrizia Lo CascioDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy. Electronic address: plocascio@unime.it.
Anthea MillerDepartment of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy. Electronic address: anthea.miller@icloud.com.
Noemi NicosiaDepartment of Pharmacological Screening, Jagiellonian University, Medical College, PL 30-688 Cracow, Poland; Division of Neuroscience, Vita Salute San Raffaele University, 20132, Milan, Italy. Electronic address: nicosia.noemi@hsr.it.
Angelo FumiaDepartment of Clinical and Experimental Medicine, University of Messina, Padiglione C, A. O. U. Policlinico "G. Martino", 98147 Messina, Italy. Electronic address: angelofumia@gmail.com.
Simona PergolizziDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy. Electronic address: spergolizzi@unime.it.
University of Messina · ITJagiellonian University · PLLuigi Sacco Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In December 2019, a new single-stranded RNA coronavirus, SARS-CoV-2, appeared in China and quickly spread around the world leading to a pandemic. Infection with SARS-CoV-2 generates symptoms ranging from asymptomatic to severe, occasionally requiring hospitalization in intensive care units, and, in more severe cases, leading to death. Scientists and researchers around the world have made a real race against time to develop various vaccines to slow down and stop the spread of the virus. In addition to conventional viral vector vaccines, new generation mRNA vaccines, BNT152b2 (Comirnaty) and mRNA-1273 (Spikevax), have been developed respectively by Pfizer/BioNTech and Moderna. These vaccines act on immune cells to induce an immune response with the production of specific antibodies against Spike protein of SARS-CoV-2, and to stimulate the differentiation of T and B memory cells. The objective of this review is to provide a detailed picture of the validity of these new vaccines and the safety of vaccination. Not only was the immunogenic effect of mRNA vaccines evaluated, but also the psychosocial impact they had on the population. The data collected show that this type of vaccine can also be an excellent candidate for future treatment and eradication of possible new pathologies with viral and non-viral etiology.

Indexed as

COVID-19COVID-19 VaccinesImmunogenicity, VaccineVaccinationHumansSARS-CoV-2Spike Glycoprotein, CoronavirusCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ComirnatyImmunitySARS-CoV-2SpikevaxVaccination

Identifiers

PMID35963787
PMCPMC9359511
OpenAlexW4291396464

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.