Evidence map›Paper›PMID 35964190›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG): A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS.

Deborah A Levine, Alden L Gross, Emily M Briceño, Nicholas Tilton, Rachael Whitney, Dehua Han, Bruno J Giordani, Jeremy B Sussman, Rodney A Hayward, James F Burke and 13 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 1 country.

Deborah A LevineDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School Public Health, Baltimore, MD, USA.
Emily M BriceñoDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
Nicholas TiltonDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
Rachael WhitneyDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
Dehua HanDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
Bruno J GiordaniDepartment of Psychiatry & Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.
Jeremy B SussmanDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
Rodney A HaywardDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
James F BurkeDepartment of Neurology and Stroke Program, University of Michigan, Ann Arbor, MI, USA.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Andrew E MoranDepartment of Medicine, Division of General Medicine, Columbia University, New York, NY, USA.
Sarah TomDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA.
Darrell J GaskinDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Stephen SidneyKaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Kristine YaffeDepartments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, San Francisco, CA, USA.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Timothy M HughesDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Oscar L LopezUniversity of Pittsburgh, Pittsburgh, PA, USA.
Norrina Bai AllenDepartment of Internal Medicine, Northwestern University, Chicago, IL, USA.
Andrzej T GaleckiDepartment of Internal Medicine and Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USColumbia University · USJohns Hopkins University · USKaiser Permanente · USNational Institute of Neurological Disorders and Stroke · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Pittsburgh · USUniversity of Washington · USVA Ann Arbor Healthcare System · USWake Forest University · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WILLIAMSON, JEFF DOUGLAS · 2016 to 2020
$12.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL127659NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL130114NIA NIH HHS K01 AG050699NIA NIH HHS K01 AG050723NIA NIH HHS L30 AG074138NIA NIH HHS P30 AG024824NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG040282NIA NIH HHS R01 AG051827NIA NIH HHS R01 AG054069NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG063887NIA NIH HHS R01 AG068629NIA NIH HHS R35 AG071916NIA NIH HHS RF1 AG068410NINDS NIH HHS R01 NS029993NINDS NIH HHS R01 NS102715
6 · The paper itself

Abstract

backgroundEthnic differences in cognitive decline have been reported. Whether they can be explained by differences in systolic blood pressure (SBP) is uncertain.

objectiveDetermine whether cumulative mean SBP levels explain differences in cognitive decline between Hispanic and White individuals.

methodsPooled cohort study of individual participant data from six cohorts (1971-2017). The present study reports results on SBP and cognition among Hispanic and White individuals. Outcomes were changes in global cognition (GC) (primary), executive function (EF) (secondary), and memory standardized as t-scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1 SD difference in cognition. Median follow-up was 7.7 (Q1-Q3, 5.2-20.1) years.

resultsWe included 24,570 participants free of stroke and dementia: 2,475 Hispanic individuals (median age, cumulative mean SBP at first cognitive assessment, 67 years, 132.5 mmHg; 40.8% men) and 22,095 White individuals (60 years,134 mmHg; 47.3% men). Hispanic individuals had slower declines in GC, EF, and memory than White individuals when all six cohorts were examined. Two cohorts recruited Hispanic individuals by design. In a sensitivity analysis, Hispanic individuals in these cohorts had faster decline in GC, similar decline in EF, and slower decline in memory than White individuals. Higher time-varying cumulative mean SBP was associated with faster declines in GC, EF, and memory in all analyses. After adjusting for time-varying cumulative mean SBP, differences in cognitive slopes between Hispanic and White individuals did not change.

conclusionWe found no evidence that cumulative mean SBP differences explained differences in cognitive decline between Hispanic and White individuals.

Indexed as

Blood PressureCognitionAgedCohort StudiesFemaleHispanic or LatinoHumansMaleRisk FactorsWhite PeopleBlood pressurecognitiondementiaethnic groupsHispanic Americans

Identifiers

PMID35964190
PMCPMC10041434
OpenAlexW4290844214

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.