Evidence map›Paper›PMID 35965009›Full record

ArticleMethods in enzymology2022

Transcriptional regulation by a RecQ helicase.

Subrata Debnath, Xing Lu, Sudha Sharma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Subrata DebnathDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, United States.
Xing LuDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, United States.
Sudha SharmaDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, United States; National Human Genome Center, College of Medicine, Howard University, Washington, DC, United States. Electronic address: sudha.sharma@howard.edu.
Howard University · US

Funding

Molecular Analysis of RECQ1 Functions in Genome MaintenanceSC1GM093999 · NIGMS · HOWARD UNIVERSITY · PI SHARMA, SUDHA · 2010 to 2019
$3.0M
NIGMS NIH HHS SC1 GM093999
6 · The paper itself

Abstract

RecQ helicases participate in a variety of DNA metabolic processes through their multiple biochemical activities. In vitro characterization and cellular studies have suggested that RECQ1 (also known as RECQL or RECQL1) performs its diverse functions through specific interactions with DNA and protein partners. We have taken an unbiased approach to determine the contribution of RECQ1 in genome maintenance and as a putative susceptibility factor in breast cancer. Here, we provide methodology to map the genome-wide binding sites of RECQ1 together with the profiling of RECQ1-dependent transcriptome to investigate its role in gene regulation. The described approach will be helpful to develop a mechanistic framework for elucidating critical functions of RECQ1 and other RecQ homologs in distinct chromatin and biological contexts.

Indexed as

Breast NeoplasmsRecQ HelicasesDNAFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansDNARecQ HelicasesChIP-seqGenomic stabilityHelicaseRecQRNA-seqTranscription

Identifiers

PMID35965009
PMCPMC9379128
OpenAlexW4226145767

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.