Evidence map›Paper›PMID 35965572›Full record

ArticleFrontiers in oncology2022

Epigenome-wide gene-age interaction study reveals reversed effects of

Ziang Xu, Yan Gu, Jiajin Chen, Xinlei Chen, Yunjie Song, Juanjuan Fan, Xinyu Ji, Yanyan Li, Wei Zhang, Ruyang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ziang XuJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Yan GuJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Jiajin ChenDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Xinlei ChenJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Yunjie SongDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Juanjuan FanDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Xinyu JiDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Yanyan LiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Wei ZhangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Ruyang ZhangDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation serves as a reversible and prognostic biomarker for oral squamous cell carcinoma (OSCC) patients. It is unclear whether the effect of DNA methylation on OSCC overall survival varies with age. As a result, we performed a two-phase gene-age interaction study of OSCC prognosis on an epigenome-wide scale using the Cox proportional hazards model. We identified one CpG probe, cg11676291

Indexed as

ageDNA methylationgene–age interaction analysisOSCCoverall survival

Identifiers

PMID35965572
PMCPMC9366171
OpenAlexW4288077256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.