ArticleFrontiers in cardiovascular medicine2022
Comparison of three non-insulin-based insulin resistance indexes in predicting the presence and severity of coronary artery disease.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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42 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies.Cardiovascular diabetology · 2025Pooled it
- An online interpretable machine learning model for predicting cardiometabolic multimorbidity risk in patients with type 2 diabetes mellitus.Scientific reports · 2026Article
- Insulin-resistance indices and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome stage 2: a comparative analysis of eGDR, TyG and METS-IR.Diabetology & metabolic syndrome · 2026Article
- Association between vitamin D status and insulin resistance in Korean adolescents: differential effects of obesity using non-insulin-based indices.BMC pediatrics · 2026Article
- Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project.Frontiers in endocrinology · 2026Article
- Association between Triglyceride-glucose index and coronary artery in-stent restenosis: A case-control study in an Iranian patient population.ARYA atherosclerosis · 2026Article
- Prognostic value of non-insulin-based insulin resistance indices in patients with newly diagnosed coronary artery disease: a cohort study.Frontiers in cardiovascular medicine · 2026Article
- Comprehensive Analysis of the Relationship Between Cardiometabolic Index and Coronary Heart Disease.International journal of general medicine · 2026Article
- Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men.Archives of endocrinology and metabolism · 2025Article
- Comparisons of three novel markers for insulin resistance to predict incident cardiovascular disease: a Korean cohort study from three different regions.European journal of medical research · 2025Article
- Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.Lipids in health and disease · 2025Article
- The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age.Cardiovascular diabetology · 2025Article
- Triglyceride-glucose index as a superior marker of insulin resistance for predicting long-term major adverse cardiovascular events following coronary artery bypass grafting in China.Scientific reports · 2025Article
- Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study.ARYA atherosclerosis · 2025Article
- Association between metabolic score for insulin resistance and lower limb pain among the elderly: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Triglyceride to high density lipoprotein cholesterol ratio and major adverse cardiovascular events in ACS patients undergoing PCI.Scientific reports · 2024Article
- Changes in the metabolic score for insulin resistance index for risk prediction of stroke in middle-aged and older Chinese population.The EPMA journal · 2024Article
- Association Between Different Insulin Resistance Indices and Heart Failure in US Adults With Diabetes Mellitus.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- METS-IR/HOMA-IR and MAFLD in U.S. adults: dose-response correlation and the effect mediated by physical activity.BMC endocrine disorders · 2024Article
- Sex differences in the association between metabolic score for insulin resistance and the reversion to normoglycemia in adults with prediabetes: a cohort study.Diabetology & metabolic syndrome · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Insulin resistance (IR) has emerged as a risk factor for coronary heart disease (CAD), but there is currently insufficient data on the association of non-insulin-based IR indexes [triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride and glucose (TyG) index, and metabolic score for IR (METS-IR)] with the presence and severity of CAD. Thus, the present study aimed to examine the relationship between these three non-insulin-based IR indexes and CAD, as well as to further compare the predictive values of each index. Materials and methods: In total, 802 consecutive patients who underwent coronary angiography for suspected CAD from January 2016 to April 2017 were included in this study and were divided into the control group ( Results: The TG/HDL-C ratio, TyG index, and METS-IR in the CAD group were significantly higher than those in the control group. The TG/HDL-C ratio and METS-IR in the high GS group were significantly higher than those in the non-high GS group. Multivariate logistic regression analysis showed that the TG/HDL-C ratio and METS-IR were independent predictors for the presence of CAD {adjusted odds ratio (OR) [95% confidence interval (CI)]: 1.32 (1.02-1.70) and 1.65 (1.32-2.05), respectively}, whereas only the METS-IR was an independent predictor of the severity of CAD [adjusted OR (95% CI): 1.22 (1.02-1.47)]. Further subgroup analysis indicated that statistical significance was observed only among men, younger patients (≤ 60), and patients with prediabetes mellitus (PDM). Receiver operator characteristic (ROC) analysis showed that the METS-IR had the highest predictive value for the prediction of both the presence and severity of CAD. Conclusion: The TG/HDL-C ratio, TyG index, and METS-IR are valuable predictors of the presence and severity of CAD, and the METS-IR has the highest predictive value among the three non-insulin-based IR indexes.
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