Dataset of ileum bacterial diversity in mice after heart failure due to pressure overload.

Martina E Spehlmann, Dhiraj P Dhotre, Nesrin Schmiedel, Nikita Chavan, Corinna Bang, Ashraf Y Rangrez

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Article in Data in brief, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Martina E SpehlmannDepartment of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Rosalind-Franklin Str. 12, Kiel 24105, Germany.

Dhiraj P DhotreNational Centre for Microbial Resource, National Centre for Cell Science, Pune 411021, India.

Nesrin SchmiedelDepartment of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Rosalind-Franklin Str. 12, Kiel 24105, Germany.

Nikita ChavanNational Centre for Microbial Resource, National Centre for Cell Science, Pune 411021, India.

Corinna BangInstitute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin-Strasse 12, Kiel 24105, Germany.

Ashraf Y RangrezDepartment of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Rosalind-Franklin Str. 12, Kiel 24105, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently reported the correlation of gut bacterial diversity with heart failure using a mouse model of heart failure due to pressure overload induced by transverse aortic constriction (TAC). We found that gut the bacterial diversity is significantly altered and is directly correlated to the severity of heart failure (Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Alterations (Spehlmann, 2022). In addition, stool samples that were collected for the gut microbial diversity analysis, we dissected ileum from the mice after 42 days of TAC. The total DNA was extracted to identify the bacterial diversity resided in ileum using 16S rRNA gene amplicon shotgun sequencing and downstream bioinformatics analysis to determine if it is correlated to the heart failure.

Indexed as

DysbiosisGut-heart axisGut microbiomeHeart failureIleum

Identifiers

PMID35966944

DOI10.1016/j.dib.2022.108498

PMCPMC9363940

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