Evidence mapPaperPMID 35967365Full record

ReviewFrontiers in immunology2022

Novel approaches for long-term lung transplant survival.

Cynthia L Miller, Jane M O, James S Allan, Joren C Madsen

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. [Immunological Aspects after Lung Transplantation].Zentralblatt fur Chirurgie · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Mesenchymal Stromal Cell Therapy in Lung Transplantation.Bioengineering (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cynthia L MillerCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Jane M OCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
James S AllanCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Joren C MadsenCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.

Funding

XENOGENIC TOLERANCE IN MICEP01HL018646 · MASSACHUSETTS GENERAL HOSPITAL · 1985 to 2005
$12.3M
Pathways to Mentorship and Research: Training the Next Generation Physician-ScientistsR25AI147393 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Jatin M Vyas · 2022 to 2022
$351k
NHLBI NIH HHS P01 HL018646NIAID NIH HHS P01 AI123086NIAID NIH HHS R25 AI147393NIAID NIH HHS U01 AI131470
6 · The paper itself

Abstract

Allograft failure remains a major barrier in the field of lung transplantation and results primarily from acute and chronic rejection. To date, standard-of-care immunosuppressive regimens have proven unsuccessful in achieving acceptable long-term graft and patient survival. Recent insights into the unique immunologic properties of lung allografts provide an opportunity to develop more effective immunosuppressive strategies. Here we describe advances in our understanding of the mechanisms driving lung allograft rejection and highlight recent progress in the development of novel, lung-specific strategies aimed at promoting long-term allograft survival, including tolerance.

Indexed as

Graft RejectionLung TransplantationHumansImmune ToleranceImmunosuppressive AgentsTransplantation, HomologousImmunosuppressive Agentsacute cellular rejection (ACR)antibody-mediated rejection (AMR)chronic lung allograft dysfunction (CLAD)ex vivo lung perfusion (EVLP)immunosuppressionlung transplantationmesenchymal stromal cells (MSCs)tissue-resident memory T-cells

Identifiers

PMID35967365
PMCPMC9363671

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.