ArticleFrontiers in neurology2022
Insulin resistance is associated with an unfavorable outcome among non-diabetic patients with isolated moderate-to-severe traumatic brain injury - A propensity score-matched study.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Comparative associations of the TyG index and HOMA2-IR with 6-month outcomes after moderate-to-severe traumatic brain injury: a single-center retrospective cohort study.Frontiers in molecular neuroscience · 2026Article
- Association between glycemic variability and the risk of acute kidney injury in patients with traumatic brain injury: a retrospective cohort study with independent cohort analysis.Frontiers in neurology · 2026Article
- Postoperative hyperglycemia in patients with traumatic brain injury: development of a prediction model.Archives of medical science : AMS · 2025Article
- The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review.Diagnostics (Basel, Switzerland) · 2024Article
- Metabolic syndrome associated with higher glycemic variability in type 1 diabetes: A multicenter cross-sectional study in china.Frontiers in endocrinology · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Background: Hyperglycemia is an independent risk factor for the poor prognosis in patients with traumatic brain injury (TBI), and stress-induced impaired insulin function is the major factor of hyperglycemia in non-diabetic patients with TBI. Several types of research suggested that insulin resistance (IR) is related to the poor prognosis of neurocritical ill patients; here we focused on the role of IR in non-diabetic patients after TBI. Methods: We performed a prospective observational study with the approval of the Ethics Committee of our institute. IR was accessed Results: A total of 85 patients with isolated moderate-to-severe TBI (admission GCS ≤ 12) were finally included in our study, 34 (40%) were diagnosed with IR with HOMA2 ≥ 1.4. After propensity score matching (PSM), 22 patients in IR group were matched to 34 patients in non-IR group. Patients with IR suffered increased systemic glycemic variation after isolated moderate-to-severe TBI. IR was a significant factor for the poor prognosis after TBI ( Conclusions: The IR estimated by HOMA2 was associated with greater GV and an unfavorable outcome after isolated moderate-to-severe TBI. Ameliorating impaired insulin sensitivity may be a potential therapeutic strategy for the management of TBI patients.
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