ArticleFrontiers in neuroscience2022
Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Effects of transcranial direct current stimulation on modulating executive functions in healthy populations: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Acute Stress Impacts Executive-Social Function: Evidence From Prefrontal Activation and fNIRS-Based Hyperscanning.Brain and behavior · 2026Trial
- Transcranial direct current stimulation of the prefrontal and visual cortices diversely affects early and late perceptual learning.Brain and behavior · 2024Trial
- Trial
- Comparative efficacy and mechanistic insights of non-invasive neuromodulation and motor rehabilitation on functional reorganization of the supplementary motor area in subacute stroke: a narrative review.Frontiers in physiology · 2026Review
- Protocol for a randomized controlled trial: efficacy and mechanisms of dual-target anodal tDCS in post-stroke cognitive impairment.Frontiers in human neuroscience · 2025Article
- Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study.Scientific reports · 2024Article
- A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits.Brain and behavior · 2024Review
- [Research progress on transcranial electrical stimulation for deep brain stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Review
- Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains.Frontiers in neuroscience · 2023Article
- Dual-site beta tACS over rIFG and M1 enhances response inhibition: A parallel multiple control and replication study.International journal of clinical and health psychology : IJCHPArticle
- Comparative efficacy of tDCS and tACS in the context of enhancing executive function under acute stress: A randomized, sham-controlled study.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior studies have focused on single-target anodal transcranial direct current stimulation (tDCS) over the right inferior frontal gyrus (rIFG) or pre-supplementary motor area (pre-SMA) to improve response inhibition in healthy individuals. However, the results are contradictory and the effect of multitarget anodal stimulation over both brain regions has never been investigated. The present study aimed to investigate the behavioral and neurophysiological effects of different forms of anodal high-definition tDCS (HD-tDCS) on improving response inhibition, including HD-tDCS over the rIFG or pre-SMA and multitarget HD-tDCS over both areas. Ninety-two healthy participants were randomly assigned to receive single-session (20 min) anodal HD-tDCS over rIFG + pre-SMA, rIFG, pre-SMA, or sham stimulation. Before and immediately after tDCS intervention, participants completed a stop-signal task (SST) and a go/nogo task (GNG). Their cortical activity was recorded using functional near-infrared spectroscopy (fNIRS) during the go/nogo task. The results showed multitarget stimulation produced a significant reduction in stop-signal reaction time (SSRT) relative to baseline. The pre-to-post SSRT change was not significant for rIFG, pre-SMA, or sham stimulation. Further analyses revealed multitarget HD-tDCS significantly decreased SSRT in both the high-performance and low-performance subgroups compared with the rIFG condition which decreased SSRT only in the low-performance subgroup. Only the multitarget condition significantly improved neural efficiency as indexed by lower △oxy-Hb after stimulation. In conclusion, the present study provides important preliminary evidence that multitarget HD-tDCS is a promising avenue to improve stimulation efficacy, establishing a more effective montage to enhance response inhibition relative to the commonly used single-target stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.