Evidence map›Paper›PMID 35969506›Full record

ArticleACS nano2022

Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation.

Annelies C Wauters, Jari F Scheerstra, Irma G Vermeijlen, Roel Hammink, Marjolein Schluck, Laura Woythe, Hanglong Wu, Lorenzo Albertazzi, Carl G Figdor, Jurjen Tel and 2 more

Abstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Review
  3. IL-2 Free Expansion of T Cells with Immunofilaments.Advanced healthcare materials · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. CAR T Cell Nanosymbionts: Revealing the Boundless Potential of a New Dyad.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Annelies C WautersBio-Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Jari F ScheerstraBio-Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Irma G VermeijlenBio-Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0002-4803-2509
Roel HamminkDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Marjolein SchluckDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Laura WoytheDepartment of Biomedical Engineering, Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0002-3125-130X
Hanglong WuBio-Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0002-8042-9952
Lorenzo AlbertazziDepartment of Biomedical Engineering, Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0002-6837-0812
Carl G FigdorDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Jurjen TelDepartment of Biomedical Engineering, Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Loai K E A AbdelmohsenBio-Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0002-0094-1893
Jan C M van HestBio-Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0001-7973-2404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanosized artificial antigen-presenting cells (aAPCs), synthetic immune cell mimics that aim to activate T cells

Indexed as

Antigen-Presenting CellsLymphocyte ActivationImmunotherapyLigandsPolyethylene GlycolsLigandsPolyethylene Glycolsantibody densityartificial antigen-presenting cellsbiodegradable polymersomesnano-immunotherapynanoparticle morphologyT cell activation

Identifiers

PMID35969506
PMCPMC9527792

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.