Evidence map›Paper›PMID 35970014›Full record

ArticleESMO open2022

PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment.

J Thouvenin, C Van Marcke, L Decoster, G Raicevic, K Punie, M Vandenbulcke, R Salgado, E Van Valckenborgh, B Maes, S Joris and 33 more

Open access · goldAbstract read
In one paragraph

Article in ESMO open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 2 countries.

J ThouveninHospices Civils de Lyon, Medical Oncology, Lyon, France; Institut Jules Bordet, Medical Oncology Clinic, Brussels, Belgium.
C Van MarckeUCLouvain, Ottignies-Louvain-la-Neuve, Belgium.
L DecosterUZ Brussel, Medical Oncology, Brussels, Belgium.
G RaicevicSciensano, Brussels, Belgium.
K PunieKU Leuven University Hospitals Leuven, General Medical Oncology, Leuven, Belgium.
M VandenbulckeSciensano, Brussels, Belgium.
R SalgadoGasthuisZusters Antwerpen, Pathology, Antwerp, Belgium.
E Van ValckenborghSciensano, Brussels, Belgium.
B MaesLaboratory of Molecular Diagnostics, Jessa Hospital Campus Virga Jesse, Hasselt, Belgium.
S JorisUZ Brussel, Medical Oncology, Brussels, Belgium.
D Vander SteichelFondation contre le Cancer, Schaerbeek, Belgium.
K VrankenPediatric Oncology, WIV-ISP, Leuven, Belgium.
S JacobsKU Leuven Hospital, Leuven.
F DedeurwaerdereLaboratory of Pathology, AZ Delta, Roeselare, Belgium.
G MartensLaboratoriumgeneeskunde, AZ Delta, Roeselare, Belgium.
H DevosLaboratoriumgeneeskunde, AZ Sint-Jan, Bruges, Belgium.
F P DuhouxUCLouvain, Ottignies-Louvain-la-Neuve, Belgium.
M RasschaertUniversitair Ziekenhuis Antwerpen, Medical Oncology, Antwerpen, Belgium; Medical Oncology, AZ Monica, Deurne, Belgium.
P PauwelsUniversitair Ziekenhuis Antwerpen, Pathology, Antwerpen, Belgium.
K GeboesDivision of Digestive Oncology, Department of Gastroenterology, UZ Gent, Gent, Belgium; Department of Internal Medicine and Pediatrics, UZ Gent, Gent, Belgium.
J CollignonMedical Oncology, CHU de Liege - Hospital Sart Tilman, Liège, Belgium.
S TejparKU Leuven Hospital, Leuven.
J-L CanonGrand Hôpital de Charleroi Site Notre Dame, Service d'Oncologie-Hématologie, Charleroi, Belgium.
M PeetersUniversitair Ziekenhuis Antwerpen, Oncology, Antwerpen, Belgium.
A RuttenGZA Ziekenhuizen Campus Sint-Vincentius, Medical Oncology, Antwerpen, Belgium.
T Van de MooterGZA Ziekenhuizen Campus Sint-Vincentius, Medical Oncology, Antwerpen, Belgium.
J VermeijZNA Middelheim, Medical Oncology, Antwerpen, Belgium.
D SchrijversZNA, Antwerpen, Belgium.
W DemeyAZ Klina, Medical Oncology, Brasschaat, Belgium.
W LybaertGZA Ziekenhuizen Campus Sint-Vincentius, Medical Oncology, Antwerpen, Belgium.
J Van HuysseAZ Sint-Jan Brugge-Oostende, Pathology, Brugge, Belgium.
J MebisLaboratory of Molecular Diagnostics, Jessa Hospital Campus Virga Jesse, Hasselt, Belgium.
A AwadaInstitut Jules Bordet, Medical Oncology Clinic, Anderlecht, Belgium.
K B M ClaesUGent, Gent, Belgium.
A HebrantSciensano, Brussels, Belgium.
J Van der MeulenUGent, Gent, Belgium.
B DelafontaineUZ Gent, Gent, Belgium.
I Vanden BemptKU Leuven Hospital, Leuven, Belgium.
J MaetensSciensano, Brussels, Belgium.
M de HemptinneSciensano, Brussels, Belgium.
S RotteyMedical Oncology Department, UZ Gent, Gent, Belgium.
P AftimosInstitut Jules Bordet, Medical Oncology Clinic, Anderlecht, Belgium.
J De GrèveUZ Brussel, Medical Oncology, Brussels, Belgium. Electronic address: Jacques.degreve@uzbrussel.be.
Sciensano (Belgium) · BEKU Leuven · BEAntwerp University Hospital · BEGZA Ziekenhuizen Campus Sint-Augustinus · BEAZ Delta · BEAZ Sint-Jan · BEGhent University · BEGhent University Hospital · BEInstitut Jules Bordet · BEJessa Hospital · BEUCLouvain · BEAZ Klina · BEAZ Sint-Lucas · BECentre Hospitalier Universitaire de Liège · BEGrand Charleroi Hospital · BEHospices Civils de Lyon · FRInstitut Scientifique de Santé Publique · BEProvince of Antwerp · BEStichting tegen Kanker · BEZiekenhuisnetwerk Antwerpen Stuivenberg · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PRECISION is an initiative from the Belgian Society of Medical Oncology (BSMO) in collaboration with several stakeholders, encompassing four programs that aim to boost genomic and clinical knowledge with the ultimate goal to offer patients with metastatic solid tumors molecularly guided treatments. The PRECISION 1 study has led to the creation of a clinico-genomic database. The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) and GeNeo studies will increase the number of patients with advanced cancer that have comprehensive genotyping of their cancer. The PRECISION 2 project consists of investigator-initiated phase II studies aiming to provide access to a targeted drug for patients whose tumors harbor actionable mutations in case the matched drug is not available through reimbursement or clinical trials in Belgium.

Indexed as

NeoplasmsPrecision MedicineBelgiumGenomicsHumansMedical Oncologygenomic alterationsgenomic-driven therapymetastatic tumorsmolecular tumor boardnext-generation sequencing (NGS)

Identifiers

PMID35970014
PMCPMC9434164
OpenAlexW4290960433

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.