ArticleNature biomedical engineering2022
Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging.
Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- OptoCENTAL: a standardized, bench-testing platform based on phantoms for validating optical systems aimed at clinical monitoring of the placenta.Journal of biomedical optics · 2026Article
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Multi-layer self-calibrated algorithm for transabdominal fetal pulse oximetry: simulation andJPhys photonics · 2026Article
- Real-Time High-Definition Hyperspectral Endoscopy via Spatial-Temporal Low-Frequency-Stochastic Spectral Encoding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Patient-specific deep offline artificial pancreas for blood glucose regulation in type 1 diabetes.Smart health (Amsterdam, Netherlands) · 2026Article
- Digital instrument simulator platform to support the development of noninvasive optical NIR device for placenta monitoring.Journal of biomedical optics · 2026Article
- Noninvasive monitoring of fetal tissue oxygenation level using time-domain NIRS.Journal of biomedical optics · 2025Article
- Finite Element Modeling of Abdominal Near-Infrared Spectroscopy for Infant Splanchnic Oximetry.International journal for numerical methods in biomedical engineering · 2025Article
- A Wireless and Wearable Multimodal Sensor to Non-Invasively Monitor Transabdominal Placental Oxygen Saturation and Maternal Physiological Signals.Biosensors · 2024Article
- Sensitivity analysis of transabdominal fetal pulse oximetry using MRI-based simulations.Biomedical optics express · 2024Article
- Reflective optical imaging for scattering medium using chaotic laser.Journal of biomedical optics · 2024Article
- Recovering fetal signals transabdominally through interferometric near-infrared spectroscopy (iNIRS).Biomedical optics express · 2023Article
- The human placenta project: Funded studies, imaging technologies, and future directions.Placenta · 2023Review
- Non-invasive estimation of hemoglobin, bilirubin and oxygen saturation of neonates simultaneously using whole optical spectrum analysis at point of care.Scientific reports · 2023Article
- Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies.Open medicine (Warsaw, Poland) · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Direct assessment of blood oxygenation in the human placenta can provide information about placental function. However, the monitoring of placental oxygenation involves invasive sampling or imaging techniques that are poorly suited for bedside use. Here we show that placental oxygen haemodynamics can be non-invasively probed in real time and up to 4.2 cm below the body surface via concurrent frequency-domain diffuse optical spectroscopy and ultrasound imaging. We developed a multimodal instrument to facilitate the assessment of the properties of the anterior placenta by leveraging image-reconstruction algorithms that integrate ultrasound information about the morphology of tissue layers with optical information on haemodynamics. In a pilot investigation involving placentas with normal function (15 women) or abnormal function (9 women) from pregnancies in the third trimester, we found no significant differences in baseline haemoglobin properties, but statistically significant differences in the haemodynamic responses to maternal hyperoxia. Our findings suggest that the non-invasive monitoring of placental oxygenation may aid the early detection of placenta-related adverse pregnancy outcomes and maternal vascular malperfusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.