Evidence map›Paper›PMID 35973713›Full record

ReviewAnnual review of pharmacology and toxicology2023

CaMKII as a Therapeutic Target in Cardiovascular Disease.

Oscar E Reyes Gaido, Lubika J Nkashama, Kate L Schole, Qinchuan Wang, Priya Umapathi, Olurotimi O Mesubi, Klitos Konstantinidis, Elizabeth D Luczak, Mark E Anderson

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Precision Cardiogenomics in Athletes.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  15. Article
  16. Review
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  19. Review
  20. Synergistic antiarrhythmic mechanism of IJournal of translational medicine · 2025
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Oscar E Reyes GaidoDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Lubika J NkashamaCleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA.
Kate L ScholeDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Qinchuan WangDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Priya UmapathiDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Olurotimi O MesubiDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Klitos KonstantinidisDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Elizabeth D LuczakDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Mark E AndersonDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email: Mark.Anderson@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USCleveland Clinic Lerner College of Medicine · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
CaMKII signaling in physiology, heart failure and arrhythmiasR35HL140034 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ANDERSON, MARK E · 2018 to 2022
$5.2M
Immersive Training in GlycosciencesK12HL141952 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASCALL, VINCENT CHARLES, SCHNAAR, RONALD L · 2018 to 2022
$4.8M
NHLBI NIH HHS K12 HL141952NHLBI NIH HHS R35 HL140034NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

CaMKII (the multifunctional Ca

Indexed as

Cardiovascular DiseasesCardiovascular SystemArrhythmias, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2HumansSignal TransductionCalcium-Calmodulin-Dependent Protein Kinase Type 2arrhythmiascalciumCaMKIIcardiovascular diseaseheart failurekinase

Identifiers

PMID35973713
PMCPMC11019858
OpenAlexW4293870377

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.