ArticleJournal of the American Society of Nephrology : JASN2022
Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD.
Article in Journal of the American Society of Nephrology : JASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Trial
- Estimated Tubular Secretion of Creatinine and Risk of Kidney Failure: The AASK Trial.Kidney medicine · 2026Article
- Association of Proximal Tubule Secretion With Hyperkalemia Risk, Treatment Response, and Outcomes in Heart Failure With Preserved Ejection Fraction.Kidney medicine · 2026Article
- Tubular Secretory Reserve: A Long-Term Sentinel for Surgical Resilience?Kidney international reports · 2026Article
- Kidney Tubule Secretion and AKI After Cardiac Surgery.Kidney international reports · 2026Article
- Tubular secretion in chronic kidney disease: from established physiology to clinical utility.Frontiers in cell and developmental biology · 2026Review
- Kidney Tubule Secretion Can Discriminate the Cause of Acute Kidney Injury in Cirrhosis.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Markers of Kidney Tubule Secretion and Future Risk of Sepsis-Associated Acute Kidney Injury Among REGARDS Participants.Kidney medicine · 2025Article
- Assessing Tubular Function, an Ignored Component of CKD, Might Be a Difference Maker!Journal of the American Society of Nephrology : JASN · 2022Article
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundKidney tubular secretion is an essential mechanism for clearing many common antihypertensive drugs and other metabolites and toxins. It is unknown whether novel measures of tubular secretion are associated with adverse events (AEs) during hypertension treatment.
methodsAmong 2089 SPRINT (Systolic Blood Pressure Intervention Trial) participants with baseline eGFR <60 ml/min per 1.73 m
resultsOverall, 30% of participants experienced at least one AE during a median follow-up of 3.0 years. In multivariable models adjusted for eGFR and albuminuria, lower (worse) secretion scores at baseline were associated with greater risk of the composite AE outcome (hazard ratio per 1-SD lower secretion score, 1.16; 95% confidence interval, 1.04 to 1.27). In analyses of the individual AEs, lower secretion score was associated with significantly greater risk of AKI, serious electrolyte abnormalities, and ambulatory hyperkalemia. Associations were similar across randomized treatment assignment groups.
conclusionAmong SPRINT participants with CKD, worse tubular secretion was associated with greater risk of AEs, independent of eGFR and albuminuria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.