Evidence map›Paper›PMID 35976439›Full record

ArticleAmino acids2022

Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period.

Svetlana Baskal, Bibiana Beckmann, Laura Stahmer, Corinna Peter, Bettina Bohnhorst, Anibh Martin Das, Dimitrios Tsikas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Svetlana BaskalInstitute of Toxicology, Core Unit Proteomics, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
Bibiana BeckmannInstitute of Toxicology, Core Unit Proteomics, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
Laura StahmerClinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30623, Hannover, Germany.
Corinna PeterClinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30623, Hannover, Germany.
Bettina BohnhorstClinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30623, Hannover, Germany.
Anibh Martin Das *Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30623, Hannover, Germany.
Dimitrios Tsikas *Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. tsikas.dimitros@mh-hannover.de.
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk samples of ten lactating women during the neonatal period. SIRT1 and SIRT3 correlated directly with citrullination, asymmetric dimethylation and glycation of L-arginine, hydroxylation and glycation of L-lysine. SIRT1 and SIRT3 correlated inversely with the hydroxylation of L-proline. SIRT1 and SITR3 tended to correlate inversely with oxidative stress measured as malondialdehyde. Our study suggests that SIRT1 and SIRT3 may modulate PTMs in human breast milk cells.

Indexed as

Sirtuin 3FemaleHumansInfant, NewbornLactationMilk, HumanProtein Processing, Post-TranslationalSirtuin 1SIRT1 protein, humanSIRT3 protein, humanSirtuin 1Sirtuin 3AGEsAmino acidsAsymmetric dimethylarginineCitrullinationHuman breast milkOxidative stressPTMSirtuins

Identifiers

PMID35976439
PMCPMC9708795
OpenAlexW4292289115

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.