Synthesis in AIDS (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 5 institutions in 2 countries.
Boghuma K TitanjiDivision of Infectious Diseases, Emory University School of Medicine.
Zeyuan WangDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Junyu ChenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Qin HuiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Kaku So-ArmahBoston University Medical School, MA.
Matthew FreibergCardiovascular Medicine Division and Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, TN.
Amy C JusticeYale University School of Medicine, New Haven.
Xu KeYale University School of Medicine, New Haven.
Vincent C MarconiDivision of Infectious Diseases, Emory University School of Medicine.
Yan V SunDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Emory University · USAtlanta VA Health Care System · USVA Connecticut Healthcare System · USBoston University · USVA Tennessee Valley Healthcare System · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African AncestryR01DK125187 · NIDDK · EMORY UNIVERSITY · PI MARCONI, VINCENT CHARLES, SUN, YAN · 2020 to 2024
$4.1M
Phase II study to evaluate the efficacy and safety of baricitinib for reduction of HIV in the central nervous systemR01MH128158 · NIMH · EMORY UNIVERSITY · PI Christina Gavegnano, Vincent Charles Marconi · 2022 to 2026
$3.2M
Feature selection of DNA methylation biosignatures for neuropathy with comorbid drug abuse in the setting of HIV infectionR01DA047820 · NIDA · YALE UNIVERSITY · PI AOUIZERAT, BRADLEY E, XU, KE · 2018 to 2022
$2.9M
Defining the impact of injection drug use on antiretroviral therapy and HIV treatment outcomes: an (epi)genomic approachR01DA047063 · NIDA · YALE UNIVERSITY · PI AOUIZERAT, BRADLEY E, XU, KE · 2018 to 2022
$2.4M
Methylome-wide and mQTL analysis of HIV progression in the context of cocaine useR01DA042691 · NIDA · YALE UNIVERSITY · PI XU, KE · 2016 to 2019
$1.6M
Novel Mechanisms Driving Excess Atherosclerotic Cardiovascular Disease Risk in the Context of HIV: The Role of Liver InjuryK01HL134147 · NHLBI · BOSTON MEDICAL CENTER · PI SO-ARMAH, KAKU · 2016 to 2020
objectivesElevated plasma levels of sCD14 predict all-cause mortality in people with HIV (PWH). Epigenetic regulation plays a key role in infection and inflammation. To reveal the epigenetic relationships between sCD14, immune function and disease progression among PWH, we conducted an epigenome-wide association study (EWAS) of sCD14 and investigated the relationship with mortality. DESIGN AND
methodsDNA methylation (DNAm) levels of peripheral blood samples from PWH in the Veterans Aging Cohort Study (VACS) were measured using the Illumina Infinium Methylation 450K (n = 549) and EPIC (850K) BeadChip (n = 526). Adjusted for covariates and multiple testing, we conducted an epigenome-wide discovery, replication, and meta-analysis to identify significant associations with sCD14. We then examined and replicated the relationship between the principal epigenetic sites and survival using Cox regression models.
findingsWe identified 118 DNAm sites significantly associated with sCD14 in the meta-analysis of 1075 PWH. The principal associated DNAm sites mapped to genes (e.g. STAT1, PARP9, IFITM1, MX1, and IFIT1) related to inflammation and antiviral response. Adjusting for multiple testing, 10 of 118 sCD14-associated DNAm sites significantly predicted survival time conditional on sCD14 levels.
conclusionThe identification of DNAm sites independently predicting survival may improve our understanding of prognosis and potential therapeutic targets among PWH.
Indexed as
DNA MethylationHIV InfectionsCohort StudiesEpigenesis, GeneticGenome-Wide Association StudyHumansInflammationLipopolysaccharide ReceptorsMaleLipopolysaccharide Receptors
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection. · full record | Socratic