Evidence mapPaperPMID 35983045Full record

ArticleFrontiers in immunology2022

Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host.

E Yaneth Osorio, Zbigniew Gugala, Grace T Patterson, Genesis Palacios, Erika Cordova, Ashanti Uscanga-Palomeque, Bruno L Travi, Peter C Melby

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. CALLY index and bone mineral density as risk factors for adjacent vertebral fracture after balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: a retrospective analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
  2. Article
  3. Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Impact of sepsis on bone marrow mesenchymal stem cells and its implications for hematopoiesis and immunosuppression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Elucidating the role played by bone marrow in visceral leishmaniasis.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

E Yaneth OsorioDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, United States.
Zbigniew GugalaDepartment of Orthopedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, TX, United States.
Grace T PattersonDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, United States.
Genesis PalaciosDepartment of Parasitology, Universidad de la Laguna, San Cristóbal de La Laguna, Spain.
Erika CordovaDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, United States.
Ashanti Uscanga-PalomequeDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, United States.
Bruno L TraviDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, United States.
Peter C MelbyDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, United States.
The University of Texas Medical Branch at Galveston · USUniversidad de La Laguna · ES

Funding

Mechanisms of Parasite Dissemination in Visceral LeishmaniasisR01AI130126 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Peter C. Melby · 2021 to 2022
$1.1M
EMERGING AND TROPICAL INFECTIOUS DISEASEST32AI007526 · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · 1997 to 2025
$819k
NIAID NIH HHS R01 AI130126NIAID NIH HHS T32 AI007526
6 · The paper itself

Abstract

Inflammation has a role in the pathogenesis of childhood malnutrition. We investigated the effect of malnutrition and inflammatory challenge on bone marrow composition and bone health. We studied an established murine model of moderate acute malnutrition at baseline and after acute inflammatory challenge with bacterial lipopolysaccharide (LPS), a surrogate of Gram-negative bacterial sepsis, or

Indexed as

Fatty Acids, Omega-3MalnutritionAnimalsBone DensityBone MarrowCytokinesFish OilsInflammasomesInflammationLipopolysaccharidesMiceCytokinesFatty Acids, Omega-3Fish OilsInflammasomesLipopolysaccharidesadipocytebonebone marrowLeishmania donovanilipopolysaccharidemalnutritionosteoclast

Identifiers

PMID35983045
PMCPMC9380851
OpenAlexW4289518442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.