Evidence map›Paper›PMID 35983566›Full record

ArticleThe World Allergy Organization journal2022

Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis.

Hye Yung Yum, Ji Su Lee, Jung Min Bae, Sooyoung Lee, Yun Hee Kim, Myongsoon Sung, Song-I Yang, Jeongmin Lee, Mi-Hee Lee, Dong Hun Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Artificial intelligence in pediatric allergy research.European journal of pediatrics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Hye Yung YumDepartment of Pediatrics, Seoul Medical Center, Seoul, South Korea.
Ji Su LeeDepartment of Dermatology, Seoul National University Hospital, Seoul, South Korea.
Jung Min BaeDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Sooyoung LeeDepartment of Pediatrics, Ajou University School of Medicine, Suwon, South Korea.
Yun Hee KimDepartment of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Myongsoon SungDepartment of Pediatrics, Soonchunhyang University Gumi Hospital, Soonchunhyang University School of Medicine, Gumi, South Korea.
Song-I YangDepartment of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Jeongmin LeeDepartment of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Mi-Hee LeeDepartment of Pediatrics, Incheon Medical Center, Incheon, South Korea.
Dong Hun LeeDepartment of Pediatrics, Seoul Medical Center, Seoul, South Korea.
Yonsei University · KRSeoul Medical Center · KRAjou University · KRCatholic University of Korea · KRHallym University Sacred Heart Hospital · KRIncheon Medical Center · KRSoonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A cluster study to classify atopic dermatitis (AD) phenotypes into subgroups is required to better understand and manage the disease owing to the heterogeneity of its clinical features. This study aimed to identify the phenotypic subgroups of childhood AD according to allergic sensitization. In 258 children with AD, hierarchical cluster analysis based on specific immunoglobulin (Ig) E sensitization revealed four distinct clusters. Cluster A (n = 71) revealed no IgE sensitization, whereas cluster B (n = 28) showed sensitization to egg white only. Cluster B was highly associated with early-onset AD (<3 months) and a family history of atopic diseases. Cluster C (n = 68) and D (n = 91), sensitized to multiple foods and inhalants, respectively, showed a higher prevalence of skin infection within the last 1 year than others. Cluster D was related to late-onset AD (>12 months) and had more atopic comorbidities. In addition, cluster D showed the most severely impaired health-related quality of life and more frequent use of immunosuppressants. Therefore, childhood AD can be classified into 4 clusters based on the allergic sensitization status, and clinical phenotypes and treatment strategy may be different according to clusters.

Indexed as

AllergyAtopic dermatitisChildrenCluster analysisSensitization

Identifiers

PMID35983566
PMCPMC9357948
OpenAlexW4289688408

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.