Evidence map›Paper›PMID 35986314›Full record

ArticleBMC psychiatry2022

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients.

Peiwei Xu, Yuanmei Tao, Hang Zhang, Meijiang Jin, Hanmei Xu, Shoukang Zou, Fang Deng, Lijuan Huang, Hong Zhang, Xiaolan Wang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Peiwei Xu *Department of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Yuanmei Tao *Department of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Hang ZhangDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Meijiang JinDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Hanmei XuDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Shoukang ZouDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Fang DengDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Lijuan HuangDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Hong ZhangDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Xiaolan WangDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Xiaowei TangDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Zaiquan DongDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Yanping WangDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Li YinDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China. yli009@163.com.ORCID 0000-0002-7448-0284
Xueli SunDepartment of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China. sunxueli58@163.com.ORCID 0000-0003-0125-8145
Sichuan University · CNChengdu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment.

methodsAfter recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis.

resultsThe gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress.

conclusionsOur results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression.

trial registrationChiCTR, ChiCTR2000033402, 31/05/2020, http://www.chictr.org.cn/index.aspx.

Indexed as

Major Depressive DisorderAdolescentAsian PeopleChildDNA MethylationEthnicityHumansAdolescentChronic childhood stressDNA methylationMajor depressive disorderTreatment response

Identifiers

PMID35986314
PMCPMC9392312
OpenAlexW4292376015

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.