Evidence map›Paper›PMID 35986494›Full record

ArticlePhysiological reports2022

Hydrogen sulfide mitigates skeletal muscle mitophagy-led tissue remodeling via epigenetic regulation of the gene writer and eraser function.

Mahavir Singh, Sathnur Pushpakumar, Yuting Zheng, Rubens P Homme, Irina Smolenkova, Sri Prakash L Mokshagundam, Suresh C Tyagi

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mahavir SinghDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.ORCID 0000-0002-2415-3314
Sathnur PushpakumarDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Yuting ZhengDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Rubens P HommeDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Irina SmolenkovaDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Sri Prakash L MokshagundamDivision of Endocrinology, Metabolism and Diabetes and Robley Rex VA Medical Center, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Suresh C TyagiDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
University of Louisville · US

Funding

miRNA Mechanism of Acute Kidney Injury in AgingR01DK116591 · NIDDK · UNIVERSITY OF LOUISVILLE · PI SEN, UTPAL, TYAGI, SURESH C. · 2018 to 2022
$2.2M
Remote Hind Limb Ischemia Mechanism of CardioprotectionR01HL139047 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, SURESH C. · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL139047NIDDK NIH HHS R01 DK116591
6 · The paper itself

Abstract

Ketone bodies (KB) serve as the food for mitochondrial biogenetics. Interestingly, probiotics are known to promote KB formation in the gut (especially those that belong to the Lactobacillus genus). Furthermore, Lactobacillus helps produce folate that lowers the levels of homocysteine (Hcy); a hallmark non-proteinogenic amino acid that defines the importance of epigenetics, and its landscape. In this study, we decided to test whether hydrogen sulfide (H

Indexed as

Hydrogen SulfideAnimalsEpigenesis, GeneticFibrosisMiceMitophagyMuscle, SkeletalHydrogen Sulfide1-carbon metabolismcystathionine β synthasehomocysteinemitochondria

Identifiers

PMID35986494
PMCPMC9391604
OpenAlexW4293660358

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.