Evidence mapPaperPMID 35987367Full record

ArticleThe Journal of pediatrics2023

Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes.

T Michael O'Shea, Hannah M Register, Joe X Yi, Elizabeth T Jensen, Robert M Joseph, Karl C K Kuban, Jean A Frazier, Lisa Washburn, Mandy Belfort, Andrew M South and 11 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 1 country.

T Michael O'SheaDepartment of Pediatrics, The University of North Carolina, Chapel Hill, NC.
Hannah M RegisterDepartment of Pediatrics, The University of North Carolina, Chapel Hill, NC.
Joe X YiFrank Porter Graham Child Development Institute, The University of North Carolina, Chapel Hill, NC.
Elizabeth T JensenDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC.
Robert M JosephDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA.
Karl C K KubanDepartment of Pediatrics and Neurology, Boston Medical Center, Boston, MA.
Jean A FrazierEunice Kennedy Shriver Center and Department of Psychiatry, University of Massachusetts Chan Medical Center, Worcester, MA.
Lisa WashburnDepartment of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC.
Mandy BelfortDepartment of Pediatric Newborn Medicine, Harvard Medical School, Boston, MA.
Andrew M SouthDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC; Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC.
Hudson P SantosSchool of Nursing & Health Studies, University of Miami, Coral Gables, FL.
Jeffrey ShenbergerDepartment of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC.
Eliana M PerrinDepartment of Pediatrics, Johns Hopkins University School of Medicine and Nursing, Baltimore, MD.
Amanda L ThompsonDepartment of Anthropology, The University of North Carolina, Chapel Hill, NC.
Rachana SinghDepartment of Pediatrics, Tufts Children's Hospital, Tufts University School of Medicine, Boston, MA.
Julie RollinsDepartment of Pediatrics, The University of North Carolina, Chapel Hill, NC.
Semsa GogcuDepartment of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC.
Keia SandersonDepartment of Internal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
Charles WoodDepartment of Pediatrics, Duke University School of Medicine, Durham, NC.
Rebecca C FryDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC.
ELGAN-ECHO Pulmonary/Obesity Group
University of North Carolina at Chapel Hill · USWake Forest University · USBoston Medical Center · USBoston University · USDuke University · USHarvard University · USJohns Hopkins University · USTufts University · USUniversity of Massachusetts Chan Medical School · USUniversity of Miami · US

Funding

Molecular Antecedents of Brain Damage in Preterm InfantsU01NS040069 · CHILDREN'S HOSPITAL BOSTON · 2001 to 2005
$17.2M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2001 to 2025
$6.9M
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born PretermR01HL146818 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MARK C CHAPPELL, Hossam Shaltout · 2023 to 2023
$775k
Carolina Population CenterP2CHD050924 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$590k
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUH3OD023348 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$0k
NHLBI NIH HHS K23 HL148394NHLBI NIH HHS L40 HL148910NHLBI NIH HHS R01 HL146818NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD092374NIEHS NIH HHS P30 ES010126NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

objectiveTo evaluate associations between changes in weight, length, and weight/length ratio during infancy and outcomes later in life among individuals born extremely preterm. STUDY

designAmong participants in the Extremely Low Gestational Age Newborn (ELGAN) study, we measured weight and length at discharge from the neonatal intensive care unit (NICU) and at age 2 years and evaluated neurocognitive, psychiatric, and health outcomes at age 10 years and 15 years. Using multivariable logistic regression, we estimated associations between gains in weight, length, and weight/length ratio z-scores between discharge and 2 years and outcomes at 10 and 15 years. High gain was defined as the top quintile of change; low gain, as the bottom quintile of change.

resultsHigh gains in weight and weight/length were associated with greater odds of obesity at 10 years, but not at 15 years. These associations were found only for females. High gain in length z-score was associated with lower odds of obesity at 15 years. The only association found between high gains in growth measures and more favorable neurocognitive or psychiatric outcomes was between high gain in weight/length and lower odds of cognitive impairment at age 10 years.

conclusionsDuring the 2 years after NICU discharge, females born extremely preterm with high gains in weight/length or weight have greater odds of obesity at 10 years, but not at 15 years. Infants with high growth gains in the 2 years after NICU discharge have neurocognitive and psychiatric outcomes in middle childhood and adolescence similar to those of infants with lower gains in weight and weight/length.

Indexed as

Infant, Extremely PrematurePremature BirthAdolescentChildChild, PreschoolFemaleGestational AgeHumansInfantInfant, NewbornIntensive Care Units, NeonatalObesityOutcome Assessment, Health Careasthmagrowthneurodevelopmentobesitypreterm birth

Identifiers

PMID35987367
PMCPMC10242541
OpenAlexW4292161265

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.