Evidence map›Paper›PMID 35988908›Full record

ReviewHeart rhythm2023

Neuromodulation therapy for atrial fibrillation.

Maham F Karatela, Marat Fudim, Joseph P Mathew, Jonathan P Piccini

Open access · greenAbstract readReview
In one paragraph

Review in Heart rhythm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maham F KaratelaCardiac Electrophysiology Section, Duke Heart Center and Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.
Marat FudimCardiac Electrophysiology Section, Duke Heart Center and Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.
Joseph P MathewDepartment of Anesthesiology, Duke University, Durham, North Carolina.
Jonathan P PicciniCardiac Electrophysiology Section, Duke Heart Center and Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina. Electronic address: jonathan.piccini@duke.edu.
Duke University · US

Funding

Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)R01AG074185 · NIA · DUKE UNIVERSITY · PI MATHEW, JOSEPH P, PICCINI, JONATHAN PAUL · 2021 to 2025
$3.7M
Congestion Phenotypes and Splanchnic Nerve Modulation in Chronic Heart FailureK23HL151744 · NHLBI · DUKE UNIVERSITY · PI FUDIM, MARAT · 2021 to 2022
$376k
NHLBI NIH HHS K23 HL151744NIA NIH HHS R01 AG074185
6 · The paper itself

Abstract

Atrial fibrillation has a multifactorial pathophysiology influenced by cardiac autonomic innervation. Both sympathetic and parasympathetic influences are profibrillatory. Innovative therapies targeting the neurocardiac axis include catheter ablation or pharmacologic suppression of ganglionated plexi, renal sympathetic denervation, low-level vagal stimulation, and stellate ganglion blockade. To date, these therapies have variable efficacy. As our understanding of atrial fibrillation and the cardiac nervous system expands, our approach to therapeutic neuromodulation will continue evolving for the benefit of those with AF.

Indexed as

Atrial FibrillationCatheter AblationAutonomic Nervous SystemHeartHeart RateHumansSympathectomyAtrial fibrillationAutonomicsGanglionated plexiNeurocardiac axisNeuromodulation

Identifiers

PMID35988908
PMCPMC10224761
OpenAlexW4292223522

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.