Evidence map›Paper›PMID 35992143›Full record

ArticleFrontiers in endocrinology2022

Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice.

Bradley B Jamieson, Aleisha M Moore, Dayanara B Lohr, Simone X Thomas, Lique M Coolen, Michael N Lehman, Rebecca E Campbell, Richard Piet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bradley B JamiesonCentre for Neuroendocrinology and Department of Physiology, University of Otago, Dunedin, New Zealand.
Aleisha M MooreBrain Health Research Institute and Department of Biological Sciences, Kent State University, Kent, OH, United States.
Dayanara B LohrBrain Health Research Institute and Department of Biological Sciences, Kent State University, Kent, OH, United States.
Simone X ThomasCentre for Neuroendocrinology and Department of Physiology, University of Otago, Dunedin, New Zealand.
Lique M CoolenBrain Health Research Institute and Department of Biological Sciences, Kent State University, Kent, OH, United States.
Michael N LehmanBrain Health Research Institute and Department of Biological Sciences, Kent State University, Kent, OH, United States.
Rebecca E CampbellCentre for Neuroendocrinology and Department of Physiology, University of Otago, Dunedin, New Zealand.
Richard PietCentre for Neuroendocrinology and Department of Physiology, University of Otago, Dunedin, New Zealand.
Kent State University · USUniversity of Otago · NZ

Funding

The role of Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons in the pathogenesis of polycystic ovarian syndromeR00HD096120 · NICHD · KENT STATE UNIVERSITY · PI MOORE, ALEISHA · 2021 to 2023
$689k
NICHD NIH HHS R00 HD096120
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is associated with elevated androgen and luteinizing hormone (LH) secretion and with oligo/anovulation. Evidence indicates that elevated androgens impair sex steroid hormone feedback regulation of pulsatile LH secretion. Hyperandrogenemia in PCOS may also disrupt the preovulatory LH surge. The mechanisms through which this might occur, however, are not fully understood. Kisspeptin (KISS1) neurons of the rostral periventricular area of the third ventricle (RP3V) convey hormonal cues to gonadotropin-releasing hormone (GnRH) neurons. In rodents, the preovulatory surge is triggered by these hormonal cues and coincident timing signals from the central circadian clock in the suprachiasmatic nucleus (SCN). Timing signals are relayed to GnRH neurons, in part,

Indexed as

KisspeptinsPolycystic Ovary SyndromeSuprachiasmatic NucleusAndrogensAnimalsArginineArginine VasopressinFemaleGonadotropin-Releasing HormoneHumansLuteinizing HormoneMiceNeuronsPregnancyVasopressinsAndrogensArginineArginine VasopressinGonadotropin-Releasing HormoneKiss1 protein, mouseKisspeptinsLuteinizing HormoneVasopressinsandrogen receptorcircadianelectrophysiologyGnRHLH surgePCOStract-tracing

Identifiers

PMID35992143
PMCPMC9388912
OpenAlexW4289866242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.