ArticleAmerican journal of respiratory and critical care medicine2022
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
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Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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0cells of the map it votes in
61citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
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Who cites it
61 citing papers in PubMed, 110 citations in OpenAlex.
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- Integrating Network Pharmacology, Machine Learning, and Experimental Validation to Elucidate the Mechanism of Cardamonin in Treating Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2025Article
- Saracatinib Promotes Hippocampal Myelin Regeneration and Oligodendrocyte Precursor Cell Maturation by Inhibiting the NOTCH1 Signaling Pathway in Epileptic Mice.Neurochemical research · 2025Article
- A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases.Nature biomedical engineering · 2025Article
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- Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications.MedComm · 2025Review
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- Emerging Concepts in Therapeutic Interventions for Idiopathic Pulmonary Fibrosis.Seminars in respiratory and critical care medicine · 2025Review
- Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis.Respiratory research · 2025Article
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1 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors at 9 institutions in 7 countries.
Farida AhangariSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-4144-9395
Christine BeckerInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.
Daniel G FosterDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Maurizio ChioccioliSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Meghan NelsonDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Keriann BekeDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Xing WangInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.
Aurelien JustetSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Taylor AdamsSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Benjamin ReadheadInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.
Carly MeadorDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Kelly CorrellDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Loukia N LiliInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.
Helen M RoybalDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Kadi-Ann RoseSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Shuizi DingSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Thomas BarnthalerSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Natalie BrionesDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Giuseppe DeIuliisSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Jonas C SchuppSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-7714-8076
Qin LiSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Norihito OmoteSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Yael AschnerDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Lokesh SharmaSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Katrina W KopfDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Björn MagnussonDiscovery Biology, Discovery Sciences, Research & Development, AstraZeneca, Gothenburg, Sweden.
Ryan HicksBioPharmaceuticals Research & Development Cell Therapy, Research, and Early Development, Cardiovascular, Renal, and Metabolism (CVRM), AstraZeneca, Gothenburg, Sweden.
Anna BackmarkDiscovery Biology, Discovery Sciences, Research & Development, AstraZeneca, Gothenburg, Sweden.
Charles S Dela CruzSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Ivan RosasDepartment of Medicine, Baylor College of Medicine, Houston, Texas; and.
Leslie P CousensEmerging Innovations, Discovery Sciences, Research & Development, AstraZeneca, Boston, Massachusetts.
Joel T DudleyInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.
Naftali KaminskiSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-5917-4601
Gregory P DowneyDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Yale University · USNational Jewish Health · USAstraZeneca (Japan) · JPIcahn School of Medicine at Mount Sinai · USArizona State University · USAstraZeneca (Finland) · FIAstraZeneca (United States) · USBaylor College of Medicine · USMedical University of Graz · AT
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTrainingU54HG008540 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BERG, JEREMY M · 2014 to 2018
$12.8MGenomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9MAlveolar DevMAPU01HL122626 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, HAGOOD, JAMES S. · 2014 to 2018
$3.7MNormal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8MCheckpoint Function of PTPalpha in Pathological Fibrogenesis in the LungR01HL132950 · NHLBI · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL · 2016 to 2019
$2.0MUse of the Src Family Kinase Inhibitor Saracatinib in the Treatment of Pulmonary FibrosisUG3TR002445 · NCATS · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL, DUDLEY, JOEL THOMAS · 2018 to 2018
$854kNCATS NIH HHS UG3 TR002445NCATS NIH HHS UG3TR002445NCATS NIH HHS UL1 TR001863NHGRI NIH HHS U54 HG008540NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL132950NHLBI NIH HHS U01 HL122626NHLBI NIH HHS U01 HL145567NIH HHS R01HL127349NIH HHS U01HL122626NIH HHS U01HL145567NIH HHS U54HG008540
Abstract
PubMed holds no abstract for this paper.
Indexed as
Idiopathic Pulmonary FibrosisProtein Kinase InhibitorsAnimalsBenzodioxolesBleomycinFibroblastsFibrosisHumansLungMiceQuinazolinessrc-Family KinasesTransforming Growth Factor betaBenzodioxolesBleomycinProtein Kinase InhibitorsQuinazolinessaracatinibsrc-Family KinasesTransforming Growth Factor betaidiopathic pulmonary fibrosislung fibrosispreclinical modelsSrc family kinasetyrosine kinase
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What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.