Evidence map›Paper›PMID 36000328›Full record

ArticleEmerging microbes & infections2022

3D

Sebastian Schloer, Daniel Treuherz, Aileen Faist, Marlous de Witt, Katharina Wunderlich, Rainer Wiewrodt, Karsten Wiebe, Peter Barth, Joo-Hee Wälzlein, Susann Kummer and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. In Vitro and Embryonic Evaluation of RecombinantPathogens (Basel, Switzerland) · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Sebastian SchloerInstitute-Associated Research Group "Regulatory Mechanisms of Inflammation", Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.
Daniel TreuherzInstitute-Associated Research Group "Regulatory Mechanisms of Inflammation", Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.
Aileen FaistInstitute of Virology, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.
Marlous de WittInstitute of Virology, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.
Katharina WunderlichInstitute of Virology, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.
Rainer WiewrodtDepartment of Medicine A, Hematology, Oncology and Respiratory Medicine, University Hospital Münster, Münster, Germany.
Karsten WiebeDepartment of Thoracic Surgery, University Hospital Münster, Münster, Germany.
Peter BarthGerhard-Domagk-Institute of Pathology, Westfälische Wilhelms-University, Münster, Germany.
Joo-Hee WälzleinCenter for Biological Threats and Special Pathogens, Robert Koch-Institute, Berlin, Germany.
Susann KummerCenter for Biological Threats and Special Pathogens, Robert Koch-Institute, Berlin, Germany.
Anne Balkema-BuschmannFriedrich-Loeffler-Institute, Institute of Novel and Emerging Infectious Diseases, Greifswald, Germany.ORCID 0000-0001-7613-9592
Stephan LudwigInstitute of Virology, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.ORCID 0000-0003-4490-3052
Linda BrunotteInstitute of Virology, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.ORCID 0000-0001-8074-7400
Ursula RescherInstitute-Associated Research Group "Regulatory Mechanisms of Inflammation", Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, and "Cells in Motion" Interfaculty Center, University of Münster, Münster, Germany.ORCID 0000-0001-8892-319X
University of Münster · DERobert Koch Institute · DEUniversity Hospital Münster · DEFriedrich-Loeffler-Institut · DELeibniz Institute of Virology (LIV) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pandemic outbreaks of viruses such as influenza virus or SARS-CoV-2 are associated with high morbidity and mortality and thus pose a massive threat to global health and economics. Physiologically relevant models are needed to study the viral life cycle, describe the pathophysiological consequences of viral infection, and explore possible drug targets and treatment options. While simple cell culture-based models do not reflect the tissue environment and systemic responses, animal models are linked with huge direct and indirect costs and ethical questions.

Indexed as

COVID-19LungOrthomyxoviridae InfectionsAnimalsAntiviral AgentsFluoxetineHumansInfluenza A virusInfluenza, HumanInterferonsMiceSARS-CoV-2Tissue Culture TechniquesVirus ReplicationAntiviral AgentsFluoxetineInterferonsdrug repurposingEx vivo infection modelinfluenzainnate immunitySARS-CoV-2

Identifiers

PMID36000328
PMCPMC9518268
OpenAlexW4293113234

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.