Evidence map›Paper›PMID 36001365›Full record

ArticleMolecular biology of the cell2022

Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells.

Carl-Gustaf A Stenvall, Joel H Nyström, Ciarán Butler-Hallissey, Theresia Jansson, Taina R H Heikkilä, Stephen A Adam, Roland Foisner, Robert D Goldman, Karen M Ridge, Diana M Toivola

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  6. Article
  7. Mechanically guided cell fate determination in early development.Cellular and molecular life sciences : CMLS · 2024
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Carl-Gustaf A StenvallCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University.
Joel H NyströmCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University.
Ciarán Butler-HallisseyCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University.
Theresia JanssonCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University.
Taina R H HeikkiläCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University.
Stephen A AdamDepartment of Cell and Developmental Biology and.
Roland FoisnerMax Perutz Labs, Medical University of Vienna, Vienna Biocenter Campus, 1030 Vienna, Austria.
Robert D GoldmanDepartment of Cell and Developmental Biology and.
Karen M RidgeDepartment of Cell and Developmental Biology and.
Diana M ToivolaCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University.
Åbo Akademi University · FICentre National de la Recherche Scientifique · FRMax Perutz Labs · ATNorthwestern University · US

Funding

Structural basis of the specific protein-protein interactions underlying IF assemP01GM096971 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 2011 to 2021
$16.8M
Austrian Science Fund FWF W 1261NIGMS NIH HHS P01 GM096971
6 · The paper itself

Abstract

Keratin intermediate filaments convey mechanical stability and protection against stress to epithelial cells. Keratins are essential for colon health, as seen in keratin 8 knockout (K8

Indexed as

Keratin-8KeratinsAnimalsCaco-2 CellsColonCytoskeletal ProteinsEpithelial CellsHumansLamin Type AMiceNuclear EnvelopePlectinRNA, Small InterferingTamoxifenCytoskeletal ProteinsKeratin-8KeratinsLamin Type APlectinRNA, Small InterferingTamoxifen

Identifiers

PMID36001365
PMCPMC9634972
OpenAlexW4292940654

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.