ArticlePlant & cell physiology2022
Ethanol-Mediated Novel Survival Strategy against Drought Stress in Plants.
Article in Plant & cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Recent Trends in Metabolomics by NMR Spectroscopy.Angewandte Chemie (International ed. in English) · 2026Review
- Ethanol application enhances freezing stress tolerance in Arabidopsis and sugar beet.Plant molecular biology · 2026Article
- Investigating the impact of carbamazepine on tomato plant metabolism using genome-scale metabolic modelling.Scientific reports · 2026Article
- Reducing the Sinapine Levels of Camelina sativa Seeds Through Targeted Genome Editing of REF1.Plant biotechnology journal · 2026Article
- Molecular mechanisms associated with rootstock-scion interactions in rubber trees.The plant genome · 2026Article
- Effect of Deep Placement Fertilization on Soybean (Plants (Basel, Switzerland) · 2026Article
- Light photon flux density affects ethanol-mediated drought avoidance in cassava (Plant biotechnology (Tokyo, Japan) · 2025Article
- Exogenous ethanol treatment promotes glycyrrhizin accumulation in aseptically grownPlant signaling & behavior · 2025Article
- Responses of grapevine cells to physiological doses of ethanol, including induced resistance to heat stress.Plant biology (Stuttgart, Germany) · 2025Article
- Application of 4-CPA or ethanol enhances plant growth and fruit quality of phyA mutant under heat stress.Scientific reports · 2025Article
- Transcriptional gene network involved in drought stress response: application for crop breeding in the context of climate change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Chemical application improves stress resilience in plants.Plant molecular biology · 2025Review
- Development of phytochemical genomics: From decoding metabolome to functional genomics and biotechnology of plant metabolism.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- 1-Butanol treatment enhances drought stress tolerance in Arabidopsis thaliana.Plant molecular biology · 2024Article
- Artificial intelligence models for validating and predicting the impact of chemical priming of hydrogen peroxide (HPlant molecular biology · 2024Article
- Application of ethanol alleviates heat damage to leaf growth and yield in tomato.Frontiers in plant science · 2024Article
- Effects of Exogenous Ethanol Treatment in Nutrient Solution on Growth and Secondary Metabolite Contents of Three Herb Species in an Indoor Vertical Farming System.Plants (Basel, Switzerland) · 2023Article
- Mechanism of Mepiquat Chloride Regulating Soybean Response to Drought Stress Revealed by Proteomics.Plants (Basel, Switzerland) · 2023Article
- Article
Corrections and comments
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Authors and funding
34 authors at 8 institutions in 3 countries.
Funding
Abstract
Water scarcity is a serious agricultural problem causing significant losses to crop yield and product quality. The development of technologies to mitigate the damage caused by drought stress is essential for ensuring a sustainable food supply for the increasing global population. We herein report that the exogenous application of ethanol, an inexpensive and environmentally friendly chemical, significantly enhances drought tolerance in Arabidopsis thaliana, rice and wheat. The transcriptomic analyses of ethanol-treated plants revealed the upregulation of genes related to sucrose and starch metabolism, phenylpropanoids and glucosinolate biosynthesis, while metabolomic analysis showed an increased accumulation of sugars, glucosinolates and drought-tolerance-related amino acids. The phenotyping analysis indicated that drought-induced water loss was delayed in the ethanol-treated plants. Furthermore, ethanol treatment induced stomatal closure, resulting in decreased transpiration rate and increased leaf water contents under drought stress conditions. The ethanol treatment did not enhance drought tolerance in the mutant of ABI1, a negative regulator of abscisic acid (ABA) signaling in Arabidopsis, indicating that ABA signaling contributes to ethanol-mediated drought tolerance. The nuclear magnetic resonance analysis using 13C-labeled ethanol indicated that gluconeogenesis is involved in the accumulation of sugars. The ethanol treatment did not enhance the drought tolerance in the aldehyde dehydrogenase (aldh) triple mutant (aldh2b4/aldh2b7/aldh2c4). These results show that ABA signaling and acetic acid biosynthesis are involved in ethanol-mediated drought tolerance and that chemical priming through ethanol application regulates sugar accumulation and gluconeogenesis, leading to enhanced drought tolerance and sustained plant growth. These findings highlight a new survival strategy for increasing crop production under water-limited conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.