Evidence mapPaperPMID 36006159Full record

ReviewToxics2022

The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review.

Henriqueta Louro, Bruno Costa Gomes, Anne Thoustrup Saber, Anna Laura Iamiceli, Thomas Göen, Kate Jones, Andromachi Katsonouri, Christiana M Neophytou, Ulla Vogel, Célia Ventura and 7 more

Abstract readReview
In one paragraph

Review in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Henriqueta LouroDepartment of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal.ORCID 0000-0001-9744-7332
Bruno Costa GomesDepartment of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal.ORCID 0000-0002-5632-1095
Anne Thoustrup SaberNational Research Centre for the Working Environment, DK-2100 Copenhagen, Denmark.
Anna Laura IamiceliIstituto Superiore di Sanità (ISS), 00161 Rome, Italy.
Thomas GöenIPASUM, Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.ORCID 0000-0002-8226-9227
Kate JonesHealth and Safety Executive, Buxton, Derbyshire SK17 9JN, UK.ORCID 0000-0001-8923-2999
Andromachi KatsonouriCyprus State General Laboratory, Ministry of Health, P.O. Box 28648, Nicosia 2081, Cyprus.ORCID 0000-0003-2038-0648
Christiana M NeophytouCyprus State General Laboratory, Ministry of Health, P.O. Box 28648, Nicosia 2081, Cyprus.ORCID 0000-0003-0823-2888
Ulla VogelNational Research Centre for the Working Environment, DK-2100 Copenhagen, Denmark.ORCID 0000-0001-6807-1524
Célia VenturaDepartment of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal.ORCID 0000-0002-0637-2222
Axel OberemmGerman Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.
Radu Corneliu DucaUnit Environmental Hygiene and Human Biological Monitoring, Department of Health Protection, Laboratoire National de Santé (LNS), 1, Rue Louis Rech, 3555 Dudelange, Luxembourg.
Mariana F FernandezCentre of Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain.ORCID 0000-0001-6417-8914
Nicolas OleaCentre of Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain.
Tiina SantonenFinnish Institute of Occupational Health, 00250 Helsinki, Finland.ORCID 0000-0002-8150-4985
Susana ViegasPublic Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisboa, 1600-560 Lisbon, Portugal.ORCID 0000-0003-1015-8760
Maria João SilvaDepartment of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal.ORCID 0000-0002-6060-0716

Funding

European Union 733032
6 · The paper itself

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.

Indexed as

effect biomarkerexposure biomarkerhuman biomonitoringoccupational exposurepolycyclic aromatic hydrocarbons

Identifiers

PMID36006159
PMCPMC9414426

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.