Evidence map›Paper›PMID 36006772›Full record

Trial reportEmerging microbes & infections2022

Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Ji-Min Seo, Bobin Kang, Rina Song, Hanmi Noh, Cheolmin Kim, Jong-In Kim, Minsoo Kim, Dong-Kyun Ryu, Min-Ho Lee, Jeong-Sun Yang and 14 more

Open access · goldAbstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Ji-Min SeoCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0003-2687-7495
Bobin KangCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0002-0551-5391
Rina SongCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0003-3036-959X
Hanmi NohCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0001-7515-8740
Cheolmin KimCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0001-7810-5601
Jong-In KimCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0001-7376-1036
Minsoo KimCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0003-4394-6528
Dong-Kyun RyuCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0003-4237-4740
Min-Ho LeeNew Drug Development Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea.ORCID 0000-0003-0197-3456
Jeong-Sun YangCenter for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control & Prevention Agency, Cheongju, Republic of Korea.ORCID 0000-0001-5005-9738
Kyung-Chang KimCenter for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control & Prevention Agency, Cheongju, Republic of Korea.ORCID 0000-0002-1075-0804
Joo-Yeon LeeCenter for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control & Prevention Agency, Cheongju, Republic of Korea.ORCID 0000-0002-0993-9626
Hansaem LeeCenter for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control & Prevention Agency, Cheongju, Republic of Korea.ORCID 0000-0002-9430-8123
Hye-Min WooCenter for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control & Prevention Agency, Cheongju, Republic of Korea.ORCID 0000-0001-8020-3489
Jun-Won KimCenter for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control & Prevention Agency, Cheongju, Republic of Korea.ORCID 0000-0001-9393-4248
Jung-Ah ChoiScience Unit, International Vaccine Institute, Seoul, Republic of Korea.ORCID 0000-0003-2381-7374
Manki SongScience Unit, International Vaccine Institute, Seoul, Republic of Korea.ORCID 0000-0002-8279-9041
Monika Tomaszewska-KiecanaBiokinetica S.A. Phase 1 Unit, Jozefow, Poland.ORCID 0000-0001-8501-5479
Anna WołowikBiokinetica S.A. Phase 1 Unit, Jozefow, Poland.ORCID 0000-0003-2913-948X
Agnieszka KuleszaBiokinetica S.A. Phase 1 Unit, Jozefow, Poland.ORCID 0000-0002-0006-9433
Sunghyun KimCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0003-3898-0393
Keumyoung AhnCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0002-9370-5338
Nahyun JungCelltrion Inc, Incheon, Republic of Korea.
Soo-Young LeeCelltrion Inc, Incheon, Republic of Korea.ORCID 0000-0002-3306-9333
Celltrion (South Korea) · KRKorea National Institute of Health · KRBioNet Lab (Japan) · JPInternational Vaccine Institute · KRKorea Disease Control and Prevention Agency · KROsong Medical Innovation Foundation · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant morbidity and mortality worldwide. Despite a successful vaccination programme, the emergence of mutated variants that can escape current levels of immunity mean infections continue. Herein, we report the development of CT-P63, a broad-spectrum neutralizing monoclonal antibody.

Indexed as

COVID-19SARS-CoV-2AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBroadly Neutralizing AntibodiesCreatine KinaseHumansMiceSpike Glycoprotein, CoronavirusAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBroadly Neutralizing AntibodiesCreatine KinaseCT-P63Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19CT-P63monoclonal antibodyneutralizing antibodySARS-CoV-2 variants of concern

Identifiers

PMID36006772
PMCPMC9542283
OpenAlexW4293103055

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.