Evidence map›Paper›PMID 36007264›Full record

Observational studyJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2022

Expression of DEspR in acute intracerebral hemorrhage.

Riana L Schleicher, Karen Li, Ravi Mylvaganam, Matthew B Bevers, Joshua N Goldstein, W Taylor Kimberly

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Riana L SchleicherDivision of Neurocritical Care, Massachusetts General Hospital, 55 Fruit Street, Lunder 644, Boston, MA 02114, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Karen LiDivisions of Stroke, Cerebrovascular and Critical Care Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Ravi MylvaganamDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Matthew B BeversDivisions of Stroke, Cerebrovascular and Critical Care Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Joshua N GoldsteinDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
W Taylor KimberlyDivision of Neurocritical Care, Massachusetts General Hospital, 55 Fruit Street, Lunder 644, Boston, MA 02114, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: wtkimberly@mgh.harvard.edu.
Massachusetts General Hospital · USBrigham and Women's Hospital · US

Funding

Metabolomic predictors of stroke in REGARDSR01NS099209 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KIMBERLY, WILLIAM TAYLOR · 2017 to 2021
$2.4M
Therapeutic RNAi treatment for Myotonic DystrophyR61NS112447 · NINDS · UNIVERSITY OF WASHINGTON · PI CHAMBERLAIN, JOEL R · 2020 to 2020
$821k
Brain endothelium and innate immune responses after strokeR21NS120002 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KIMBERLY, WILLIAM TAYLOR · 2021 to 2021
$451k
NINDS NIH HHS R01 NS099209NINDS NIH HHS R21 NS120002NINDS NIH HHS R61 NS112447
6 · The paper itself

Abstract

objectivesNeuroinflammation and secondary injury play a central role in the pathophysiology of intracerebral hemorrhage. The dual endothelin-1/VEGFsignal-peptide receptor (DEspR) has been reported to mediate the inflammatory response after acute brain injury in a rodent model. We performed a pilot study to assess the expression of DEspR on circulating leukocytes in patients who presented with spontaneous intracerebral hemorrhage (ICH). MATERIALS AND

methodsWe performed a prospective observational study of patients presenting to two academic medical centers with ICH. Normal healthy volunteers (NHV) were also recruited for sample analysis. Whole blood was obtained, and flow cytometry was performed to examine DEspR expression on neutrophils, monocytes, and lymphocytes.

resultsA total of 19 patients were included in analysis. Median ICH volume was 39 cm

conclusionsIn this pilot study, DEspR is expressed on circulating neutrophils and monocytes in humans after ICH, with higher levels of expression in those with hypertension. Future work in larger cohorts should examine the relationship of DEspR expression with neuroinflammatory endpoints and long-term outcome.

Indexed as

Endothelin-1HypertensionCerebral HemorrhageHumansPilot ProjectsReceptors, PeptideEndothelin-1Receptors, PeptideCerebral hemorrhageHemorrhagic strokeMonocytesNeutrophils

Identifiers

PMID36007264
PMCPMC9509454
OpenAlexW4292640625

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.