Evidence map›Paper›PMID 36008954›Full record

ReviewBiomolecules2022

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs.

Nunzio Iraci, Carmelo Corsaro, Salvatore V Giofrè, Giulia Neri, Angela Maria Mezzasalma, Martina Vacalebre, Antonio Speciale, Antonina Saija, Francesco Cimino, Enza Fazio

Abstract readReview
In one paragraph

Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nunzio IraciDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-1359-8684
Carmelo CorsaroDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-1497-8750
Salvatore V GiofrèDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-3117-587X
Giulia NeriDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-4458-0022
Angela Maria MezzasalmaDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0003-2955-4317
Martina VacalebreDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0001-9199-3850
Antonio SpecialeDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-6135-3892
Antonina SaijaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-4186-3596
Francesco CiminoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0002-8954-4797
Enza FazioDepartment of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0001-9132-7073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The last few years have increasingly emphasized the need to develop new active antiviral products obtained from artificial synthesis processes using nanomaterials, but also derived from natural matrices. At the same time, advanced computational approaches have found themselves fundamental in the repurposing of active therapeutics or for reducing the very long developing phases of new drugs discovery, which represents a real limitation, especially in the case of pandemics. The first part of the review is focused on the most innovative nanomaterials promising both in the field of therapeutic agents, as well as measures to control virus spread (i.e., innovative antiviral textiles). The second part of the review aims to show how computer-aided technologies can allow us to identify, in a rapid and therefore constantly updated way, plant-derived molecules (i.e., those included in terpenoids) potentially able to efficiently interact with SARS-CoV-2 cell penetration pathways.

Indexed as

COVID-19 Drug TreatmentNanostructuresAntiviral AgentsComputersHumansSARS-CoV-2Antiviral Agentsantiviral activitydrug delivery systemsmolecular dockingnanodecoysnanosystemsSARS-CoV-2terpenoidsvirus spread control measures

Identifiers

PMID36008954
PMCPMC9405735

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.