Evidence map›Paper›PMID 36009501›Full record

ArticleBiomedicines2022

DNA Hypomethylation as a Potential Link between Excessive Alcohol Intake and Cardiometabolic Dysfunction in Morbidly Obese Adults.

Imaduddin Mirza, Dina Naquiallah, Ariej Mohamed, Uzma Abdulbaseer, Chandra Hassan, Mario Masrur, Mohamed M Ali, Shane A Phillips, Abeer M Mahmoud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Imaduddin MirzaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Dina NaquiallahDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Ariej MohamedDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Uzma AbdulbaseerDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Chandra HassanDepartment of Surgery, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Mario MasrurDepartment of Surgery, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Mohamed M AliDepartment of Physical Therapy, College of Applied Health Sciences, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8085-7132
Shane A PhillipsDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Abeer M MahmoudDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-0295-6706
University of Illinois Chicago · US

Funding

Role of Adiposomes in Diabetes-Associated Endothelial Dysfunction and Restorative Effects of Exercise and Metabolic SurgeryR01HL161386 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · 2022 to 2025
$2.9M
National Heart Lung and Blood Institute R00 HL140049-03National Heart Lung and Blood Institute R01HL161386-01NHLBI NIH HHS R01 HL161386
6 · The paper itself

Abstract

A large percentage of obese patients in the United States suffer a comorbid substance use disorder, mainly alcohol use. Alcohol consumption interferes with the absorption of dietary methyl donors such as folate required for the one-carbon metabolism pathway and subsequently for DNA methylation. In this study, we assessed the association between alcohol consumption and DNA methylation in obese subjects. We obtained visceral adipose tissue (VAT) biopsies from bariatric patients. DNA methylation of 94 genes implicated in inflammation and immunity were analyzed in VAT in relation to alcohol consumption data obtained via questionnaires. Vasoreactivity was measured in the brachial artery and the VAT-isolated arterioles. Pro-inflammatory genes were significantly hypomethylated in the heavy drinking category correlating with higher levels of circulating inflammatory cytokines. Alcohol consumption correlated positively with body mass index (BMI), fat percentage, insulin resistance, impaired lipid profile, and systemic inflammation and negatively with plasma folate and vitamin B12, inflammatory gene DNA methylation, and vasoreactivity. In conclusion, these data suggest that alcohol intake is associated with lower DNA methylation and higher inflammation and cardiometabolic risk in obese individuals.

Indexed as

adipose tissuesalcoholB vitaminscardiovascularDNA methylationfolateinflammationobesityvasodilation

Identifiers

PMID36009501
PMCPMC9406007
OpenAlexW4291414911

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.