Evidence map›Paper›PMID 36009692›Full record

ArticleAnimals : an open access journal from MDPI2022

Characteristics of tRNA-Derived Small RNAs and microRNAs Associated with Immunocompromise in an Intrauterine Growth-Restricted Pig Model.

Jianfeng Ma, Mailin Gan, Jingyun Chen, Lei Chen, Ye Zhao, Yan Zhu, Lili Niu, Shunhua Zhang, Yanzhi Jiang, Zongyi Guo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jianfeng MaDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0003-2731-5355
Mailin GanDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0001-9900-3559
Jingyun ChenDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lei ChenDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Ye ZhaoDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Yan ZhuCollege of Life Science, China West Normal University, Nanchong 637009, China.
Lili NiuDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Shunhua ZhangDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Yanzhi JiangDepartment of Zoology, College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.ORCID 0000-0002-9568-557X
Zongyi GuoChongqing Academy of Animal Science, Chongqing 402460, China.
Jinyong WangChongqing Academy of Animal Science, Chongqing 402460, China.
Li ZhuDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Linyuan ShenDepartment of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Sichuan Agricultural University · CNChongqing Academy of Animal Science · CNChina West Normal University · CN

Funding

Chongqing municipal key laboratory project No.21516National Natural Science Foundation of China No.31902135; No.31972524Sichuan Science and Technology Program NO.2021YJ0265; NO.2021YFYZ0007; NO.2021ZDZX0008; NO.2020YFN0147; NO.scsztd-2022-08-09
6 · The paper itself

Abstract

Intrauterine growth restriction (IUGR) is an important cause of newborn morbidity and mortality in mammals. Transfer RNA-derived small RNA (tsRNA) has become an emerging non-coding RNA in recent years. tsRNA and microRNAs (miRNAs) share similar mechanisms, which are involved in various biological processes. In this study, the pig was used as a model of IUGR, and the tsRNA and miRNA expression profile in the spleen was characterized by RNA sequencing. A total of 361 miRNAs and 620 tsRNAs were identified, of which 22 were differentially expressed miRNA (DEM) and 25 differentially expressed tsRNA (DET). tRF-5c were the primary tsRNA type making up more than 90%, and the most abundantly expressed tsRNAs are from tRNA-Gly-GCC. Functional enrichment analysis found that those DETs and DEMs have been implicated in the immune system process. Protein-protein interaction (PPI) network analysis revealed ssc-miR-370, ssc-miR-206, tiRNA-Ser-TGA-001 and tRF-Val-AAC-034 could be major regulators. TNF, TLR4, CD44, MAPK1 and STAT1 were predicted hub target genes. Those DETs and DEMs may regulate the T-cell receptor signaling pathway and Toll-like receptor signaling pathway to mediate the immunocompromise caused by IUGR. The results discussed in this article uncover the potential role of tsRNAs and miRNAs in IUGR porcine spleen.

Indexed as

immunocompromiseintrauterine growth restrictionmicroRNApig modelspleentsRNA

Identifiers

PMID36009692
PMCPMC9404909
OpenAlexW4292261165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.