ArticleBiology2022
CRISPRi-Mediated Down-Regulation of the Cinnamate-4-Hydroxylase (C4H) Gene Enhances the Flavonoid Biosynthesis in
Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Transcriptome-Based Dissection of the Molecular Mechanisms Underlying Flooding Stress Responses of Eastern Cottonwood in the Floodplains of the Middle and Lower Reaches of the Yangtze River.Plants (Basel, Switzerland) · 2026Article
- Resilience of Portulaca plants to environmental stresses and the economic potential of their bioactive compounds.Planta · 2025Review
- Epigenome Engineering Using dCas Systems for Biomedical Applications and Biotechnology: Current Achievements, Opportunities and Challenges.International journal of molecular sciences · 2025Review
- Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops.Horticulture research · 2025Article
- A chromosome-levelActa pharmaceutica Sinica. B · 2025Article
- Article
- Unravelling the Significance of Seed Proteomics: Insights into Seed Development, Function, and Agricultural Applications.The protein journal · 2024Review
- Chromosome-level genome assembly of Hippophae tibetana provides insights into high-altitude adaptation and flavonoid biosynthesis.BMC biology · 2024Article
- Application and development of CRISPR technology in the secondary metabolic pathway of the active ingredients of phytopharmaceuticals.Frontiers in plant science · 2024Review
- Article
- Multi-Omics Elucidates Difference in Accumulation of Bioactive Constituents in Licorice (Molecules (Basel, Switzerland) · 2023Article
- Full-length transcriptome combined with RNA sequence analysis of Fraxinus chinensis.Genes & genomics · 2023Article
- Advances in Plant Epigenome Editing Research and Its Application in Plants.International journal of molecular sciences · 2023Review
- Plant-based expression platforms to produce high-value metabolites and proteins.Frontiers in plant science · 2022Review
- Phenolic Compounds and Flavonoids in Various Extracts ofIranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Flavonoids are an important class of natural compounds present in plants. However, despite various known biological activities and therapeutic potential, the low abundance of flavonoids in nature limits their development for industrial applications. In this study, we aimed to enhance flavonoid production by silencing cinnamate-4-hydroxylase (C4H), an enzyme involved in the branch point of the flavonoid biosynthetic pathway, using the clustered regularly interspaced short palindromic repeats interference (CRISPRi) approach. We designed three sgRNAs targeting the promoter region of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.