Evidence map›Paper›PMID 36010559›Full record

ArticleCells2022

Combination of

Fabiana Napolitano, Sarah Di Somma, Giuliano Castellano, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Anna Maria Malfitano

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  4. Review
  5. Advancements inMolecules (Basel, Switzerland) · 2024
    Review
  6. Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fabiana NapolitanoDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-9242-6046
Sarah Di SommaDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Giuliano CastellanoDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Jussara AmatoDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-6096-3544
Bruno PaganoDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7716-9010
Antonio RandazzoDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Giuseppe PortellaDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-8276-9769
Anna Maria MalfitanoDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-6193-2835
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-quadruplexes (G4s) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabilization induced by G4 ligands might potentiate the anticancer activity of agents targeting DNA or inhibiting its repair such as oncolytic viruses. This study represents the first approach combining G4 ligands, BRACO-19 (B19), pyridostatin (PDS), and the adenovirus

Indexed as

Adenoviridae InfectionsBreast NeoplasmsG-QuadruplexesAdenoviridaeAnimalsDNAHumansMaleMiceMice, NudeDNAadenovirusbreast cancerG-quadruplexoncolytic virussenescenceSTING

Identifiers

PMID36010559
PMCPMC9406944
OpenAlexW4293677300

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.