Evidence map›Paper›PMID 36010733›Full record

ArticleEntropy (Basel, Switzerland)2022

Tumor Biochemical Heterogeneity and Cancer Radiochemotherapy: Network Breakdown Zone-Model.

Argyris Dimou, Panos Argyrakis, Raoul Kopelman

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Argyris DimouDepartment of Physics and Complexity Center, University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-2207-277X
Panos ArgyrakisDepartment of Physics and Complexity Center, University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-8275-1881
Raoul KopelmanDepartment of Chemistry, and Rogel Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7770-8272

Funding

USA National Cancer Institute R01CA250499
6 · The paper itself

Abstract

Breakdowns of two-zone random networks of the Erdős-Rényi type are investigated. They are used as mathematical models for understanding the incompleteness of the tumor network breakdown under radiochemotherapy, an incompleteness that may result from a tumor's physical and/or chemical heterogeneity. Mathematically, having a reduced node removal probability in the network's inner zone hampers the network's breakdown. The latter is described quantitatively as a function of reduction in the inner zone's removal probability, where the network breakdown is described in terms of the largest remaining clusters and their size distributions. The effects on the efficacy of radiochemotherapy due to the tumor micro-environment (TME)'s chemical make-up, and its heterogeneity, are discussed, with the goal of using such TME chemical heterogeneity imaging to inform precision oncology.

Indexed as

hypoxia heterogeneityinverse percolation shell modelmonte-carlo simulationsnetwork breakdownoncology radiation modellingtumor radiotherapy

Identifiers

PMID36010733
PMCPMC9407148

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.