Evidence map›Paper›PMID 36010965›Full record

ReviewCancers2022

Recent Advances and Challenges in Cancer Immunotherapy.

Chelsea Peterson, Nathan Denlinger, Yiping Yang

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Head and neck squamous cell carcinoma: current and emerging therapeutic strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Advancing brain immunotherapy through functional nanomaterials.Drug delivery and translational research · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Embracing cancer immunotherapy with manganese particles.Cellular oncology (Dordrecht, Netherlands) · 2025
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chelsea PetersonDivision of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0002-7167-5860
Nathan DenlingerDivision of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Yiping YangDivision of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
The Ohio State University · US

Funding

Role of macrophage polarization in multi-organ fibrosis of chronic GVHDR01HL151195 · NHLBI · OHIO STATE UNIVERSITY · PI HUANG, XIAOPEI · 2020 to 2023
$2.2M
T Memory Stem Cells in CancerR01CA193167 · NCI · OHIO STATE UNIVERSITY · PI YANG, YIPING · 2016 to 2020
$2.2M
Regulation of tumor-infiltrating T cells by macrophagesR01CA260858 · NCI · OHIO STATE UNIVERSITY · PI HUANG, XIAOPEI · 2021 to 2025
$2.2M
NCI NIH HHS R01 CA193167NCI NIH HHS R01 CA260858NHLBI NIH HHS R01 HL151195NIH HHS R01CA193167NIH HHS R01CA260858NIH HHS R01HL151195
6 · The paper itself

Abstract

Cancer immunotherapy has revolutionized the field of oncology in recent years. Harnessing the immune system to treat cancer has led to a large growth in the number of novel immunotherapeutic strategies, including immune checkpoint inhibition, chimeric antigen receptor T-cell therapy and cancer vaccination. In this review, we will discuss the current landscape of immuno-oncology research, with a focus on elements that influence immunotherapeutic outcomes. We will also highlight recent advances in basic aspects of tumor immunology, in particular, the role of the immunosuppressive cells within the tumor microenvironment in regulating antitumor immunity. Lastly, we will discuss how the understanding of basic tumor immunology can lead to the development of new immunotherapeutic strategies.

Indexed as

cancer vaccinechimeric antigen receptor (CAR)-T cell therapyimmune checkpoint inhibitorimmunotherapyneoantigentumor-associated macrophages (TAMs)tumor microenvironment (TME)

Identifiers

PMID36010965
PMCPMC9406446
OpenAlexW4292260448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.