Evidence map›Paper›PMID 36011365›Full record

ArticleGenes2022

Genome-Wide Association Study Reveals Additive and Non-Additive Effects on Growth Traits in Duroc Pigs.

Yahui Xue, Shen Liu, Weining Li, Ruihan Mao, Yue Zhuo, Wenkai Xing, Jian Liu, Chuang Wang, Lei Zhou, Minggang Lei and 1 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yahui XueCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-1158-8618
Shen LiuSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Weining LiCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-0578-3812
Ruihan MaoCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yue ZhuoCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Wenkai XingJiangxi Zhengbang Breeding Co., Ltd., Nanchang 330096, China.
Jian LiuJiangxi Zhengbang Breeding Co., Ltd., Nanchang 330096, China.
Chuang WangJiangxi Zhengbang Breeding Co., Ltd., Nanchang 330096, China.
Lei ZhouCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-4080-0435
Minggang LeiJiangxi Zhengbang Breeding Co., Ltd., Nanchang 330096, China.
Jianfeng LiuCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
China Agricultural University · CNFoshan University · CNHuazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth rate plays a critical role in the pig industry and is related to quantitative traits controlled by many genes. Here, we aimed to identify causative mutations and candidate genes responsible for pig growth traits. In this study, 2360 Duroc pigs were used to detect significant additive, dominance, and epistatic effects associated with growth traits. As a result, a total number of 32 significant SNPs for additive or dominance effects were found to be associated with various factors, including adjusted age at a specified weight (AGE), average daily gain (ADG), backfat thickness (BF), and loin muscle depth (LMD). In addition, the detected additive significant SNPs explained 2.49%, 3.02%, 3.18%, and 1.96% of the deregressed estimated breeding value (DEBV) variance for AGE, ADG, BF, and LMD, respectively, while significant dominance SNPs could explain 2.24%, 13.26%, and 4.08% of AGE, BF, and LMD, respectively. Meanwhile, a total of 805 significant epistatic effects SNPs were associated with one of ADG, AGE, and LMD, from which 11 sub-networks were constructed. In total, 46 potential genes involved in muscle development, fat deposition, and regulation of cell growth were considered as candidates for growth traits, including

Indexed as

Genome-Wide Association StudyPolymorphism, Single NucleotideAnimalsMusclesPhenotypeSwineDEBVsdominanceDuroc pigsepistasisgrowth traitsGWAS

Identifiers

PMID36011365
PMCPMC9407794
OpenAlexW4292295004

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.