Evidence mapPaperPMID 36013273Full record

ReviewJournal of personalized medicine2022

Nanotechnologies in Obstetrics and Cancer during Pregnancy: A Narrative Review.

Serena Bertozzi, Bruna Corradetti, Luca Seriau, José Andrés Diaz Ñañez, Carla Cedolini, Arrigo Fruscalzo, Daniela Cesselli, Angelo Cagnacci, Ambrogio P Londero

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. The Application of Engineered Nanomaterials in Perinatal Therapeutics.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Serena BertozziBreast Unit, Department of Surgery, DAME, University Hospital of "Santa Maria della Misericordia", 33100 Udine, Italy.
Bruna CorradettiCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA.
Luca SeriauBreast Unit, Department of Surgery, DAME, University Hospital of "Santa Maria della Misericordia", 33100 Udine, Italy.
José Andrés Diaz ÑañezBreast Unit, Department of Surgery, DAME, University Hospital of "Santa Maria della Misericordia", 33100 Udine, Italy.
Carla CedoliniBreast Unit, Department of Surgery, DAME, University Hospital of "Santa Maria della Misericordia", 33100 Udine, Italy.
Arrigo FruscalzoClinic of Obstetrics and Gynecology, University Hospital of Fribourg, 1752 Fribourg, Switzerland.ORCID 0000-0002-8958-6049
Daniela CesselliInstitute of Pathology, DAME, University of Udine, University Hospital of Udine, 33100 Udine, Italy.ORCID 0000-0002-0562-7852
Angelo CagnacciAcademic Unit of Obstetrics and Gynaecology, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Infant Health, University of Genoa, 16132 Genova, Italy.ORCID 0000-0003-2714-623X
Ambrogio P LonderoEnnergi Research (Non-Profit Organisation), 33050 Lestizza, Italy.ORCID 0000-0001-6429-1220
Ospedale Santa Maria della Misericordia di Udine · ITBaylor College of Medicine · USOspedale Policlinico San Martino · ITUniversity of Fribourg · CHUniversity of Genoa · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotechnology, the art of engineering structures on a molecular level, offers the opportunity to implement new strategies for the diagnosis and management of pregnancy-related disorders. This review aims to summarize the current state of nanotechnology in obstetrics and cancer in pregnancy, focusing on existing and potential applications, and provides insights on safety and future directions. A systematic and comprehensive literature assessment was performed, querying the following databases: PubMed/Medline, Scopus, and Endbase. The databases were searched from their inception to 22 March 2022. Five independent reviewers screened the items and extracted those which were more pertinent within the scope of this review. Although nanotechnology has been on the bench for many years, most of the studies in obstetrics are preclinical. Ongoing research spans from the development of diagnostic tools, including optimized strategies to selectively confine contrast agents in the maternal bloodstream and approaches to improve diagnostics tests to be used in obstetrics, to the synthesis of innovative delivery nanosystems for therapeutic interventions. Using nanotechnology to achieve spatial and temporal control over the delivery of therapeutic agents (e.g., commonly used drugs, more recently defined formulations, or gene therapy-based approaches) offers significant advantages, including the possibility to target specific cells/tissues of interest (e.g., the maternal bloodstream, uterus wall, or fetal compartment). This characteristic of nanotechnology-driven therapy reduces side effects and the amount of therapeutic agent used. However, nanotoxicology appears to be a significant obstacle to adopting these technologies in clinical therapeutic praxis. Further research is needed in order to improve these techniques, as they have tremendous potential to improve the accuracy of the tests applied in clinical praxis. This review showed the increasing interest in nanotechnology applications in obstetrics disorders and pregnancy-related pathologies to improve the diagnostic algorithms, monitor pregnancy-related diseases, and implement new treatment strategies.

Indexed as

assisted reproduction technologydiabetesfetal growthfetal growth restrictionfetal therapynanoparticlenanotechnologypreeclampsiapregnancypreterm birthpreterm labor

Identifiers

PMID36013273
PMCPMC9410527
OpenAlexW4292253290

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.