Evidence map›Paper›PMID 36014365›Full record

ArticleMolecules (Basel, Switzerland)2022

Alteration of Biomolecular Conformation by Aluminum-Implications for Protein Misfolding Disease.

Yuhai Zhao, Aileen I Pogue, Peter N Alexandrov, Leslie G Butler, Wenhong Li, Vivian R Jaber, Walter J Lukiw

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Unraveling the molecular mechanisms of aluminium chloride-induced Alzheimer's disease.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Yuhai ZhaoLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Aileen I PogueAlchem Biotek Research, Toronto, ON M5S 1A8, Canada.
Peter N AlexandrovRussian Academy of Medical Sciences, 113152 Moscow, Russian.
Leslie G ButlerDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.ORCID 0000-0003-1547-608X
Wenhong LiDepartment of Pharmacology, Jiangxi University of TCM, Nanchang 330004, China.
Vivian R JaberLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Walter J LukiwLSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Academy of Medical Sciences · GBLouisiana State University Health Sciences Center New Orleans · USJiangxi University of Traditional Chinese Medicine · CNLouisiana State University · US

Funding

microRNA (miRNA) signaling in Alzheimer's disease(AD)R01AG038834 · NIA · LSU HEALTH SCIENCES CENTER · PI BAZAN, NICOLAS G. · 2011 to 2020
$3.3M
Gene Expression in Alzheimer's DiseaseR01AG018031 · NIA · LSU HEALTH SCIENCES CENTER · PI LUKIW, WALTER J · 2001 to 2006
$1.4M
NIA NIH HHS R01 AG018031NIA NIH HHS R01 AG038834NIH HHS AG038834NIH HHS AG18031The Brown Foundation, Joe and Dorothy Dorsett Innovation in Science Healthy Aging Award 2021-2022
6 · The paper itself

Abstract

The natural element aluminum possesses a number of unique biochemical and biophysical properties that make this highly neurotoxic species deleterious towards the structural integrity, conformation, reactivity and stability of several important biomolecules. These include aluminum's

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesNeurotoxicity SyndromesProteostasis DeficienciesAluminumAnimalsProtein ConformationAluminumadenosine triphosphate (ATP)aluminumAlzheimer’s disease (AD)biomoleculeshistone linker proteins (H1 class)prion disease (PrD)protein folding disease

Identifiers

PMID36014365
PMCPMC9412470
OpenAlexW4290998831

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.