Evidence map›Paper›PMID 36015155›Full record

ReviewPharmaceuticals (Basel, Switzerland)2022

Pharmaceutical Prevention and Management of Cardiotoxicity in Hematological Malignancies.

Anastasia Stella Perpinia, Nikolaos Kadoglou, Maria Vardaka, Georgios Gkortzolidis, Apostolos Karavidas, Theodoros Marinakis, Chrysostomi Papachrysostomou, Panagiotis Makaronis, Charikleia Vlachou, Marina Mantzourani and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Coronary atherosclerosis and chemotherapy: From bench to bedside.Frontiers in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Anastasia Stella PerpiniaDepartment of Cardiology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Nikolaos KadoglouMedical School, University of Cyprus, Nicosia 2029, Cyprus.ORCID 0000-0002-7830-3488
Maria VardakaDepartment of Hematology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Georgios GkortzolidisDepartment of Hematology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Apostolos KaravidasDepartment of Cardiology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Theodoros MarinakisDepartment of Hematology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Chrysostomi PapachrysostomouDepartment of Cardiology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Panagiotis MakaronisDepartment of Cardiology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Charikleia VlachouDepartment of Hematology, "G. Gennimatas" General Hospital, 11527 Athens, Greece.
Marina MantzouraniFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, "Laiko" General Hospital, 11527 Athens, Greece.
Dimitrios FarmakisMedical School, University of Cyprus, Nicosia 2029, Cyprus.
Konstantinos KonstantopoulosDepartment of Hematology, Medical School, National and Kapodistrian University of Athens, "Laiko" General Hospital, 11527 Athens, Greece.
General Hospital of Athens G. Genimatas · GRNational and Kapodistrian University of Athens · GRUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies. Nevertheless, many new or conventional anticancer drugs affect the cardiovascular system, resulting in various cardiac disorders, including left ventricular dysfunction, heart failure, arterial hypertension, myocardial ischemia, cardiac rhythm disturbances, and QTc prolongation on electrocardiograms. As these complications may jeopardize the significantly improved outcome of modern anticancer therapies, it is crucial to become familiar with all aspects of cardiotoxicity and provide appropriate care promptly to these patients. In addition, established and new drugs contribute to primary and secondary cardiovascular diseases prevention. This review focuses on the clinical manifestations, preventive strategies, and pharmaceutical management of cardiotoxicity in patients with hematologic malignancies undergoing anticancer drug therapy or hematopoietic stem cell transplantation.

Indexed as

anthracyclinesanticancer targeted therapiescardiotoxicityheart failureleukemialymphoma

Identifiers

PMID36015155
PMCPMC9412591
OpenAlexW4292261960

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.